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Application of functional metabolomics in biomedicine
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Jing-Xian Liu1, Jian-Yong Zhang2, *, Xiao-Fei Li1, 3, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(6) : 631 - 638
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(6): 631-638
• Review •
Application of functional metabolomics in biomedicine
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Jing-Xian Liu1, Jian-Yong Zhang2, *, Xiao-Fei Li1, 3, *
Affiliations
  • 1Basic Medicine School, Zunyi Medical University, Zunyi, Guizhou 563000, China
  • 2School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563000, China
  • 3Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China
Published: 2022-06-28 doi: 10.11855/j.issn.0577-7402.2022.06.0631
Outline
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Functional metabolomics is an extension of metabolomics, through detecting changes in endogenous metabolites that are stimulated and disturbed by a particular organism, after obtaining the biomarker, experiments were conducted to verify the functions of the biomarker and the associated enzymes, genes and proteins. The molecular mechanism of pathophysiology can be revealed systematically from the perspective of "metabolite-enzyme-gene-protein", solving the upstream and downstream biological mechanisms of metabolite association. This article reviews and analyzes the current common methods and research strategies of functional metabolomics, the exploration of disease targets and pathogenesis, and the analysis of drug action mechanisms in the field of biomedicine. At the same time, the extended research on the combination of functional metabolomics with network pharmacology and reprogramming metabolomics is summarized, and finally the application prospects of functional metabolomics are analyzed and prospected in the field of biomedicine.

functional metabolomics  /  biological markers  /  pharmacological action mechanism  /  toxicological mechanism
Jing-Xian Liu, Jian-Yong Zhang, Xiao-Fei Li. Application of functional metabolomics in biomedicine[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (6) : 631 -638 . DOI: 10.11855/j.issn.0577-7402.2022.06.0631
Funding
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  • National Natural Science Foundation of China(82060754)
  • National Natural Science Foundation of China Youth Project(81803838)
  • Capacity Building Project for Sustainable Utilization of Valuable Chinese Medicine Resources(2060302-1907-06)
  • Talent Support Project of Science and Technology of Guizhou Education Department(Qianjiaohe KY[2017]078)
  • Science and Technology Planning Project of Guizhou Province(Qiankehe Foundation [2020]1Y376)
  • Science and Technology Planning Project of Guizhou Province(Qiankehe Foundation [2019]1346)()
Appendix
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Year 2022 volume 47 Issue 6
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.06.0631
  • Receive Date：2021-07-06
  • Online Date：2025-12-17
  • Published：2022-06-28
Article Data
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History
  • Received：2021-07-06
  • Accepted：2021-08-13
Funding
National Natural Science Foundation of China(82060754)
National Natural Science Foundation of China Youth Project(81803838)
Capacity Building Project for Sustainable Utilization of Valuable Chinese Medicine Resources(2060302-1907-06)
Talent Support Project of Science and Technology of Guizhou Education Department(Qianjiaohe KY[2017]078)
Science and Technology Planning Project of Guizhou Province(Qiankehe Foundation [2020]1Y376)
Science and Technology Planning Project of Guizhou Province(Qiankehe Foundation [2019]1346)()
Affiliations
    1Basic Medicine School, Zunyi Medical University, Zunyi, Guizhou 563000, China
    2School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563000, China
    3Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China

Corresponding:

* Zhang Jian-Yong, E-mail: ;
Li Xiao-Fei, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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