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Conversion-therapeutic strategies for unresectable advanced hepatocellular carcinoma
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Yi Luo, Guo-Shan Ding, Jia-Yong Dong*
Medical Journal of Chinese People’s Liberation Army | 2022, 47(7) : 731 - 738
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(7): 731-738
• Review •
Conversion-therapeutic strategies for unresectable advanced hepatocellular carcinoma
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Yi Luo, Guo-Shan Ding, Jia-Yong Dong*
Affiliations
  • Department of Organ Transplantation, the Affiliated Changzheng Hospital of Naval Medical University, Shanghai 200003, China
Published: 2022-07-28 doi: 10.11855/j.issn.0577-7402.2022.07.0731
Outline
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Radical hepatectomy is the well-established and highly effective therapeutic tool for early- and middle-stage hepatocellular carcinoma (HCC) to improve the survival. However, the majority of HCC patients in China are not amenable to surgical excision due to the advanced tumor stage at the initial diagnosis. Therefore, it is the bottom line to convert and downstage unresectable tumor into resectable tumor in clinical practice, which is an important means for improving patient survival rate and is currently a clinical research focus as well. In recent years, the rate of conversion surgery for unresectable advanced HCC has achieved dramatic improvement thanking to the accumulating effective therapeutic arsenals, and an increasing number of patients benefit from conversion therapy. Herein, several clinically relevant issues on conversion therapy for HCC were discussed in this review, including the definition of conversion therapy, the optimal selection of patients as well as conversion strategy, and the timing of sequential surgery together with strategy and safety of surgery.

hepatocellular carcinoma  /  unresectable hepatocellular carcinoma  /  conversion therapy  /  downstaging
Yi Luo, Guo-Shan Ding, Jia-Yong Dong. Conversion-therapeutic strategies for unresectable advanced hepatocellular carcinoma[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (7) : 731 -738 . DOI: 10.11855/j.issn.0577-7402.2022.07.0731
Funding
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  • National Natural Science Foundation of China(81871262)
Appendix
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Year 2022 volume 47 Issue 7
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.07.0731
  • Receive Date：2021-07-29
  • Online Date：2025-12-16
  • Published：2022-07-28
Article Data
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History
  • Received：2021-07-29
  • Accepted：2021-09-22
Funding
National Natural Science Foundation of China(81871262)
Affiliations
    Department of Organ Transplantation, the Affiliated Changzheng Hospital of Naval Medical University, Shanghai 200003, China

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