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Research progress of Wnt/β-catenin signaling pathway in cancer stem cells
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Yu-Jia Tian1, 2, Ming Wei1, Hui Zhao3, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(8) : 831 - 837
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(8): 831-837
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Research progress of Wnt/β-catenin signaling pathway in cancer stem cells
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Yu-Jia Tian1, 2, Ming Wei1, Hui Zhao3, *
Affiliations
  • 1Graduate School, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China
  • 2Department of Respiratory and Critical Care Medicine, Dalian Third People's Hospital, Dalian, Liaoning 116091, China
  • 3Health Management Center, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China
Published: 2022-08-28 doi: 10.11855/j.issn.0577-7402.2022.08.0831
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The incidence and mortality of malignant tumors are gradually increasing all the world, and the existing diagnosis and treatment methods still can not effectively block the occurrence and development of tumors. Some studies have found that cancer stem cells (CSCs) are the cells of tumor origin, and closely related to the occurrence, development and metastasis of tumors.Early detection and intervention with effective treatment of CSCs are expected to prevent the occurrence and development of tumors. Many studies have shown that the activation of Wnt/β-catenin signaling pathway is an important link in the initiation of CSCs and the formation of tumors. Therefore, by regulating the key upstream and downstream factors of the Wnt/β-catenin pathway in CSCs, thereby regulating the activity of the Wnt/β-catenin signaling pathway, controlling tumor growth and metastasis,can provide new targets and directions for the treatment and prevention of malignant tumors. The key role of Wnt/β-catenin signal pathway in CSCs, and the related mechanisms of the important factors of the pathway in regulating the tumor growth, development and metastasis of CSCs in different organs are reviewed in present paper.

malignant tumor  /  cancer stem cells  /  Wnt/β-catenin signaling pathway  /  therapeutic target
Yu-Jia Tian, Ming Wei, Hui Zhao. Research progress of Wnt/β-catenin signaling pathway in cancer stem cells[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (8) : 831 -837 . DOI: 10.11855/j.issn.0577-7402.2022.08.0831
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  • Dalian Science and Technology Innovation Fund Program(2021JJ13SN67)
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Year 2022 volume 47 Issue 8
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.08.0831
  • Receive Date：2021-06-27
  • Online Date：2025-12-15
  • Published：2022-08-28
Article Data
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History
  • Received：2021-06-27
  • Accepted：2021-08-10
Funding
Dalian Science and Technology Innovation Fund Program(2021JJ13SN67)
Affiliations
    1Graduate School, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China
    2Department of Respiratory and Critical Care Medicine, Dalian Third People's Hospital, Dalian, Liaoning 116091, China
    3Health Management Center, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China

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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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