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Research advances of targeting DNA damage response in small cell lung cancer
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Song-Yun Zhao1, Zhi-Jie Wan2, Xi-Yuan Cao1, Yan-Yong Yang2, Chong Bai1, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(8) : 838 - 844
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(8): 838-844
• Review •
Research advances of targeting DNA damage response in small cell lung cancer
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Song-Yun Zhao1, Zhi-Jie Wan2, Xi-Yuan Cao1, Yan-Yong Yang2, Chong Bai1, *
Affiliations
  • 1Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China
  • 2Department of Marine Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
Published: 2022-08-28 doi: 10.11855/j.issn.0577-7402.2022.08.0838
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Small cell lung cancer (SCLC) is an aggressive malignancy with a 5-year survival rate of 7.2%, which is characterized by exceptionally high proliferation rate, early metastasis, and poor prognosis. In the face of DNA damage and replicative stress, the DNA damage response (DDR) elicits activation of cell cycle checkpoints to promote repair by pausing the cell cycle or, in cases of unrepairable DNA damage, stimulate programmed cell death. SCLC carries a high mutation burden and genomic instability, and almost all SCLC tumors have functional inactivation of both TP53 and RB1, which leads to the form of a dysfunctional G1/S checkpoint and results in an increased reliance on subsequent cell cycle checkpoints (S, G2/M) to ensure genome stability and correct chromosomal segregation. Therefore, under the use of radio-chemotherapy for DNA damaging, promoting the cell cycle progress by inhibiting the cycle checkpoints and increasing DNA damage by inhibiting DNA damage repair can be new strategies for targeted therapies in SCLC. In the present article, we review the advances of targeting DDR and it's pathway inhibitors in SCLC, and provide some thoughts for the targeted treatment strategies of SCLC.

DNA damage  /  DNA repair  /  small cell lung cancer  /  targeted therapy
Song-Yun Zhao, Zhi-Jie Wan, Xi-Yuan Cao, Yan-Yong Yang, Chong Bai. Research advances of targeting DNA damage response in small cell lung cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (8) : 838 -844 . DOI: 10.11855/j.issn.0577-7402.2022.08.0838
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.08.0838
  • Receive Date：2021-07-26
  • Online Date：2025-12-15
  • Published：2022-08-28
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  • Received：2021-07-26
  • Accepted：2021-09-06
Affiliations
    1Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China
    2Department of Marine Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China

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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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