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Research progress on the role of exosome-carried MMPs in intervertebral disc degeneration
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Mao-Qiang Lin1, 2, Yi-Cun Hu1, 2, Xiao-Bo Zhang3, Hai-Ying An4, Tao-Wen Guo1, 2, Xi-Dan Gao1, 2, Rui-Hao Zhang1, 2, Xiang-Yi Chen1, 2, De-Chen Yu1, 2, Hai-Yu Zhou1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(9) : 941 - 946
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(9): 941-946
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Research progress on the role of exosome-carried MMPs in intervertebral disc degeneration
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Mao-Qiang Lin1, 2, Yi-Cun Hu1, 2, Xiao-Bo Zhang3, Hai-Ying An4, Tao-Wen Guo1, 2, Xi-Dan Gao1, 2, Rui-Hao Zhang1, 2, Xiang-Yi Chen1, 2, De-Chen Yu1, 2, Hai-Yu Zhou1, 2, *
Affiliations
  • 1Department of Orthopedics, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China
  • 2Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730030, China
  • 3Department of Orthopedics, Honghui Hospital, Xi'an, Shaanxi 710000, China
  • 4Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430000, China
Published: 2022-09-28 doi: 10.11855/j.issn.0577-7402.2022.09.0941
Outline
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Low back pain caused by intervertebral disc degeneration (IVDD) has become an important disease affecting human health, the current conservative treatment and surgical treatment cannot prevent its progression. Therefore, targeted therapy starting from the molecular level has become a current research hotspot. The matrix metalloproteinases (MMPs) carried by exosomes are closely related to the disorder of extracellular matrix (ECM) components in the IVDD process, MMP-1, MMP-2,MMP-3, MMP-9, and MMP-14 overexpression is positively correlated with the severity of IVDD. MMP-8, MMP-10, and MMP-12 also participate in the occurrence and progression of IVDD to varying degrees, but the specific mechanism is still unclear. Therefore,in-depth study of the mechanism of MMP-8, MMP-10, MMP-12 involved in the occurrence of IVDD, and the development of targeted drugs for exosomes and MMP-1, MMP-2, MMP-3, MMP-9, MMP-14 have certain potential value to the molecular level treatment of IVDD. This article aims to summarize the recent research progress in the involvement of MMPs carried by exosomes in the process of IVDD, in order to provide new targets and directions for the treatment of IVDD at the molecular level.

exosomes  /  matrix metalloproteinase  /  intervertebral disc degeneration  /  molecular level
Mao-Qiang Lin, Yi-Cun Hu, Xiao-Bo Zhang, Hai-Ying An, Tao-Wen Guo, Xi-Dan Gao, Rui-Hao Zhang, Xiang-Yi Chen, De-Chen Yu, Hai-Yu Zhou. Research progress on the role of exosome-carried MMPs in intervertebral disc degeneration[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (9) : 941 -946 . DOI: 10.11855/j.issn.0577-7402.2022.09.0941
Funding
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  • Xigu District Science and Technology Support Plan Project of Lanzhou(2018-3-79)
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Year 2022 volume 47 Issue 9
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.09.0941
  • Receive Date：2021-09-06
  • Online Date：2025-12-15
  • Published：2022-09-28
Article Data
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History
  • Received：2021-09-06
  • Accepted：2021-12-25
Funding
Xigu District Science and Technology Support Plan Project of Lanzhou(2018-3-79)
Affiliations
    1Department of Orthopedics, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China
    2Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou, Gansu 730030, China
    3Department of Orthopedics, Honghui Hospital, Xi'an, Shaanxi 710000, China
    4Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430000, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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