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Objective To explore the expression of cellular prion protein (PrPC) and its relationship with prognosis in colorectal cancer (CRC). Methods A total of 50 CRC tissues and 30 corresponding normal colorectal tissues were selected from the Department of Gastrointestinal Surgery of the First People's Hospital of Taicang City from January 2016 to January 2017.The expression of PrPC was determined by immunohistochemical SP method. Spearman test was used to analyze the correlation between PrPC positive expression and clinicopathological characteristics in CRC tissue. Kaplan-Meier method was used to analyze the relationship between PrPC expression and prognosis of CRC patients, Cox proportional hazards regression model was used to analyze the influencing factors of CRC prognosis. Results High expression of PrPC was shown in CRC tissues, and positive expression rate in CRC tissues was significantly higher than in corresponding normal colorectal tissues [68.0%(34/50) vs. 20.0%(6/30), P<0.01], and PrPC expression level was associated with patient TNM stage, depth of tumor invasion, degree of tumor differentiation, presence of vascular invasion and lymph node metastasis (P<0.05). Follow up until January 2021, except for 1 case of loss of follow-up, the remaining 49 cases were fully followed up for 6-68 months. During the follow-up, 32 cases died, with a median follow-up of 48 months. Kaplan-Meier survival curve analysis showed that the survival time of the patients in the PrPC negative expression group was (62.0±7.0) months, and the 5-year overall survival rate was 50.3%; the survival time of the PrPC positive expression group was (45.0±4.1) months, the 5-year overall survival rate was 7.0%, the difference was statistically significant in the survival situation was found between the two groups (P=0.015). The results of multivariate Cox regression model analysis showed that TNM stage and positive PrPC expression were independent factors influencing the outcome of CRC patients (P<0.05). Conclusion The high expression of PrPC in CRC tissues is correlated with poor prognosis in CRC patients, suggesting that PrPC is expected to be an important indicator for determining the prognosis of CRC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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