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Research advances on vonoprazan for eradication of Helicobacter pylori
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Wen-Tao Xu1, 2, Xiang-Bo Xu1, 2, Tian-Shu Ren3, Xing-Shun Qi1, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(9) : 947 - 953
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(9): 947-953
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Research advances on vonoprazan for eradication of Helicobacter pylori
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Wen-Tao Xu1, 2, Xiang-Bo Xu1, 2, Tian-Shu Ren3, Xing-Shun Qi1, *
Affiliations
  • 1Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110840, China
  • 2Postgraduate College, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China
  • 3Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, Liaoning 110840, China
Published: 2022-09-28 doi: 10.11855/j.issn.0577-7402.2022.09.0947
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Helicobacter pylori (Hp) infection is a common chronic bacterial infection in humans, which is significantly associated with a variety of gastrointestinal diseases. Traditionally, Hp eradication is based on one type of proton pump inhibitors(PPIs) combined with two types of antibiotics. PPIs could increase the pH value in the stomach to strengthen the bactericidal or antibacterial effects of antibiotics. Vonoprazan is a new drug with a stronger acid-suppressing effect compared to PPIs. Vonoprazan-based regimens are not inferior to PPIs-based regimens for eradicating Hp and are well tolerated. This article aims to summarize the effects of vonoprazan-based treatment strategy for Hp eradication, including vonoprazan-based first-line, second-line, and third-line regimens, vonoprazan-based regimens on penicillin-allergic and clarithromycin-resistant patients, vonoprazan-based dual and first-line triple regimens, and 10-14 d vonoprazan-based regimens.

vonoprazan  /  Helicobacter pylori  /  proton pump inhibitors
Wen-Tao Xu, Xiang-Bo Xu, Tian-Shu Ren, Xing-Shun Qi. Research advances on vonoprazan for eradication of Helicobacter pylori[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (9) : 947 -953 . DOI: 10.11855/j.issn.0577-7402.2022.09.0947
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doi: 10.11855/j.issn.0577-7402.2022.09.0947
  • Receive Date：2021-09-07
  • Online Date：2025-12-15
  • Published：2022-09-28
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  • Received：2021-09-07
  • Accepted：2021-10-20
Affiliations
    1Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110840, China
    2Postgraduate College, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China
    3Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, Liaoning 110840, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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