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Research progress of small nucleolar RNA host gene 17 involved in cancer process
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Yuan Li1, 2, Xin-Xin Wang2, Shi-Yong Chen2, Xue-Qin Du2, Xiao-Jun Yang2, 3, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(9) : 932 - 940
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(9): 932-940
• Review •
Research progress of small nucleolar RNA host gene 17 involved in cancer process
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Yuan Li1, 2, Xin-Xin Wang2, Shi-Yong Chen2, Xue-Qin Du2, Xiao-Jun Yang2, 3, *
Affiliations
  • 1College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China
  • 2The Second Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou, Gansu 730000, China
  • 3Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology/Gansu Research Center of Prevention and Control Project for Digestive Oncology, the First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China
Published: 2022-09-28 doi: 10.11855/j.issn.0577-7402.2022.09.0932
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Long non-coding RNAs (lncRNAs) are composed of a group of RNAs with more than 200 nucleotides but lacking protein coding functions. It has been gradually confirmed that it plays an important role of carcinogenic or tumor suppressor genes in the development and progression of human cancer. Small nucleolar RNA host gene 17 (SNHG17) is a lncRNA located on chromosome 20q11.23. In recent years, a large number of studies have explored the potential regulatory roles of SNHG17 in a variety of human cancers [such as oral squamous cell carcinoma, gastric cancer, hepatocellular carcinom, pancreatic cancer,colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, glioma, melanoma and osteosarcoma, etc.] progression,and high expression is usually closely related to the clinicopathological characteristics of tumor patients. In addition, it can promote the proliferation and metastasis of tumor cells, while inhibiting apoptosis. Therefore, SNHG17 is considered as a potential tumor biomarker and therapeutic target. This review focuses on the relevant research reports of SNHG17 in human cancers at home and abroad in recent years, focusing on the latest insights into the expression, functional role and molecular mechanism of SNHG17 in human malignant tumors, in order to provide a theoretical basis for clinical cancer treatment.

long non-coding RNA  /  cancer  /  small nucleolar RNA host gene 17  /  biomarker
Yuan Li, Xin-Xin Wang, Shi-Yong Chen, Xue-Qin Du, Xiao-Jun Yang. Research progress of small nucleolar RNA host gene 17 involved in cancer process[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (9) : 932 -940 . DOI: 10.11855/j.issn.0577-7402.2022.09.0932
Funding
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  • Key Projects of the National Scientific Research Cultivation Program 2019-216(19SYPYA-12)
  • Innovation Base and Talent Project of Gansu Province(20JR10RA433)
  • Key Project of the Provincial Science and Technology Program of Gansu Province(21YF5WA027)
  • Scientific Research Program of the Health Industry of Gansu Province(GSWSKY2020-45)
Appendix
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Year 2022 volume 47 Issue 9
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142
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.09.0932
  • Receive Date：2021-08-22
  • Online Date：2025-12-15
  • Published：2022-09-28
Article Data
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History
  • Received：2021-08-22
  • Accepted：2021-12-13
Funding
Key Projects of the National Scientific Research Cultivation Program 2019-216(19SYPYA-12)
Innovation Base and Talent Project of Gansu Province(20JR10RA433)
Key Project of the Provincial Science and Technology Program of Gansu Province(21YF5WA027)
Scientific Research Program of the Health Industry of Gansu Province(GSWSKY2020-45)
Affiliations
    1College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China
    2The Second Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou, Gansu 730000, China
    3Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology/Gansu Research Center of Prevention and Control Project for Digestive Oncology, the First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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