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Research progress on the mechanism of Drp1 in diabetic cardiomyopathy
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Xiao-Gang Song1, Bing Wu2, *, Yong-Qing Chen3, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(9) : 926 - 931
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(9): 926-931
• Review •
Research progress on the mechanism of Drp1 in diabetic cardiomyopathy
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Xiao-Gang Song1, Bing Wu2, *, Yong-Qing Chen3, *
Affiliations
  • 1Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China
  • 2Department of Geriatrics, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
  • 3Department of Cardiology, Gansu Provincial Central Hospital, Lanzhou, Gansu 730070, China
Published: 2022-09-28 doi: 10.11855/j.issn.0577-7402.2022.09.0926
Outline
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Diabetic cardiomyopathy is one of the chronic irreversible and serious cardiovascular complications in diabetic patients. Recent studies have shown that the mitochondrial dysfunction caused by the disturbance of mitochondrial dynamic balance is closely related to the occurrence of diabetic cardiomyopathy. Dynamin related protein 1 (Drp1) is an important regulator of mitochondrial fission. Studies have shown that increased activity of Drp1 in diabetes cardiomyocytes can lead to increased mitochondrial fission and decreased mitochondrial fusion which leads to mitochondrial dysfunction. Drp1 can lead to the occurrence and development of diabetic cardiomyopathy by inducing oxidative stress, energy metabolism disorders, apoptosis,insulin resistance, and lipotoxicity in cardiomyocytes. In addition, inhibition of Drp1 activity may improve cardiac function in diabetic cardiomyopathy. Therefore, the mechanism of Drp1 in diabetic cardiomyopathy have been reviewed in present paper in order to provide new ideas for the prevention and treatment of diabetic cardiomyopathy and drug development.

mitochondrial fission  /  dynamin related protein 1  /  diabetic cardiomyopathy  /  myocardial cell  /  damage mechanism
Xiao-Gang Song, Bing Wu, Yong-Qing Chen. Research progress on the mechanism of Drp1 in diabetic cardiomyopathy[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (9) : 926 -931 . DOI: 10.11855/j.issn.0577-7402.2022.09.0926
Funding
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  • Natural Science Foundation of Gansu Province(18JR3RA402)
  • Scientific Research Project on Health Industry of Gansu Province(GSWSKY2020-13)
  • Project of Northwest Minzu University(31920200012)
Appendix
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Year 2022 volume 47 Issue 9
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199
84
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.09.0926
  • Receive Date：2021-11-15
  • Online Date：2025-12-15
  • Published：2022-09-28
Article Data
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History
  • Received：2021-11-15
  • Accepted：2021-11-25
Funding
Natural Science Foundation of Gansu Province(18JR3RA402)
Scientific Research Project on Health Industry of Gansu Province(GSWSKY2020-13)
Project of Northwest Minzu University(31920200012)
Affiliations
    1Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China
    2Department of Geriatrics, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
    3Department of Cardiology, Gansu Provincial Central Hospital, Lanzhou, Gansu 730070, China

Corresponding:

* Chen Yong-Qing, E-mail: ;
Wu Bing, E-mail:
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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