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Research progress on the pathological effects of nuclear transcription factor TDP-43 and its application in disease diagnosis and treatment
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Jiao Yue1, 2, Qin Li3, Bing Yang4, Yu An4, Xiao-Feng Tang4, Ying-Mei Chen1, Ke-Ji Lu5, Peng Wang1, Gong-Ren Li1, Hai-Feng Pei1, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(10) : 1026 - 1033
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(10): 1026-1033
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Research progress on the pathological effects of nuclear transcription factor TDP-43 and its application in disease diagnosis and treatment
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Jiao Yue1, 2, Qin Li3, Bing Yang4, Yu An4, Xiao-Feng Tang4, Ying-Mei Chen1, Ke-Ji Lu5, Peng Wang1, Gong-Ren Li1, Hai-Feng Pei1, *
Affiliations
  • 1Department of Cardiology, General Hospital of Western Theater Command of Chinese PLA, Chengdu, Sichuan 610083, China
  • 2Clinical Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
  • 3Cadre Ward, General Hospital of Western Theater Command of Chinese PLA, Chengdu, Sichuan 610083, China
  • 4Department of Cardiology and Nephrology, 950th Hospital of Chinese PLA, Yecheng, Xinjiang 844900, China
  • 5College of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611130, China
Published: 2022-10-28 doi: 10.11855/j.issn.0577-7402.2022.10.1026
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Nuclear transcription factor TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA binding protein commonly expressed and highly conserved in evolution. In physiological state, TDP-43, when localized mainly in nucleus and cytoplasm (no more than 30%), may play a physiological role, such as participating in mRNA transcription, splicing, translation, transport and maintaining the stability of mRNA, while its mislocalization in mitochondria might play a corresponding pathological role. Recent researches found that, in addition to produce a marked effect in neurodegenerative diseases, TDP-43 also plays an important role in the pathological process of tumors, male infertility, osteoarthritis (OA) and other diseases. Therefore, the gene expression, subcellular organelle translocation, function and the relationship with diseases of TDP-43 have attracted more and more attention. The research progress of pathological effects of TDP-43 has been reviewed in present paper, so as to provide more help for diagnosis and treatment of related diseases.

TAR DNA-binding protein 43  /  subcellular localization  /  neurodegenerative disease  /  pathology
Jiao Yue, Qin Li, Bing Yang, Yu An, Xiao-Feng Tang, Ying-Mei Chen, Ke-Ji Lu, Peng Wang, Gong-Ren Li, Hai-Feng Pei. Research progress on the pathological effects of nuclear transcription factor TDP-43 and its application in disease diagnosis and treatment[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (10) : 1026 -1033 . DOI: 10.11855/j.issn.0577-7402.2022.10.1026
Funding
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  • National Natural Science Foundation of China(81970241)
  • Key Project of the General Hospital of Western Theater Command of Chinese PLA(2021-XZYG-A03)
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Year 2022 volume 47 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.10.1026
  • Receive Date：2021-11-22
  • Online Date：2025-12-15
  • Published：2022-10-28
Article Data
Affiliations
History
  • Received：2021-11-22
  • Accepted：2022-04-13
Funding
National Natural Science Foundation of China(81970241)
Key Project of the General Hospital of Western Theater Command of Chinese PLA(2021-XZYG-A03)
Affiliations
    1Department of Cardiology, General Hospital of Western Theater Command of Chinese PLA, Chengdu, Sichuan 610083, China
    2Clinical Medical College, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
    3Cadre Ward, General Hospital of Western Theater Command of Chinese PLA, Chengdu, Sichuan 610083, China
    4Department of Cardiology and Nephrology, 950th Hospital of Chinese PLA, Yecheng, Xinjiang 844900, China
    5College of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611130, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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