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Objective To explore the cumulative metabolic indicators and the related risk factors for restenosis after intervention of lower extremity arteriosclerosis obliterans (LEASO). Methods Data were collected of 110 patients with arterial occlusive symptoms of low limbs who admitted to the Department of Hypertension and Endocrinology, Army Characteristic Medical Center, Army Medical University from January 2007 to July 2021 and met the criteria. All patients underwent low limbs interventional surgery and were followed up for more than 2 years. CT angiography (CTA) and ultrasound of both low limbs arteries were performed 2 years after surgery to clarify whether restenosis occurred and, based on the results of CTA and ultrasound, patients were divided into restenosis group (n=37) and non-restenosis group (n=73). The patients' basic information, pre- and post-operative hematological indices at 6 months, 1 year and 2 years were collected to compare and analyze the differences in basic clinical information, baseline values of metabolic indices (Xbaseline) and cumulative exposure values (Xcum) between patients in the restenosis group and non-restenosis group, and binary logistic regression models were used to analyze the risk factors for post-interventional revascularization in patients with LEASO. Results The incidence was 33.6% of restenosis 2 years after intervention in patients with lower extremity arterial occlusive disease. The percentage of patients with smoking, the percentage of patients with Pan Atlantic Collaborative Group (TASC) typeⅡ (hereafter referred to as TASC type Ⅱ) C or D femoropopliteal artery lesions(hereafter referred to as TASC typeⅡ), hypersensitive C-reactive protein (hs-CRP), cumulative hypersensitive C-reactive protein(hs-CRPCum), cumulative low-density lipoprotein cholesterol (LDL-CCum), and cumulative triacylglycerol (TGCum) were significantly higher in restenosis group than those in non-restenosis group (P<0.05). The percentage of patients with regular postoperative use of antiplatelet agents and ankle-brachial index (ABI) were significantly lower than those in non-restenosis group (P<0.05). Binary logistic regression analysis showed that smoking (OR=4.158, P=0.040), TASC Ⅱ typing (OR=4.3, P=0.036), hs-CRPCum (OR=1.160,P=0.013), LDL-CCum (OR=2.313, P=0.003), and TGCum (OR=1.668, P=0.015) were the risk factors for restenosis 2 years after surgery, and regular postoperative use of antiplatelet drugs was a protective factor (OR=0.038, P=0.000). Conclusions Smoking,TASC Ⅱ typing, hs-CRPCum, LDL-CCum, and TGCum were the risk factors for restenosis of blood vessels after intervention in patients with lower extremity atherosclerotic occlusive disease. The regular use of postoperative antiplatelet drugs was a protective factor. Continuous smoking cessation, intensive lipid lowering, and anti-inflammation are the key factors to reduce the occurrence of postoperative restenosis, and early intervention of vascular lesions (TASC A-B) has better long-term effects.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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