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Glioma is of the most common malignant tumors in the central nervous system. The prognosis of patients is poor, and its effective treatment has always been a major clinical challenge. In tumor cells, genetic instability often leads to a large number of mutations. The expression of nonsynonymous mutations can produce tumor-specific antigens, called neo-antigens, which have high immunogenicity. They could activate specific T cells to produce an immune response and become a new tumor immunotherapy target. Among the tumor vaccines targeting neo-antigens, the mRNA tumor vaccine has obvious advantages: easy access, low cost, high safety, and great stability. Therefore, a neo-antigen mRNA vaccine is likely to become an effective treatment for glioma. At present, some clinical trials have proved the safety and effectiveness of these vaccines. This article reviews the research progress of the neo-antigen tumor mRNA vaccine and its application in glioma therapy, and predict the direction of future research.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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