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Objective To study and evaluate the cardiovascular function of patients with psoriasis vulgaris (PV) by analyzing the dynamic Korotkoff's sound trend diagram data from visual blood pressure measurements. Methods A total of 52 PV patients, visiting and/or admitted in the Department of Dermatology of Air Force Medical Center of PLA during July 14 to August 31, 2021, were recruited as PV group, and another 51 examiners in the Health Examination Center of Air Force Medical Center of PLA during August 2-31, 2021 were levied as healthy control group. Routine blood tests and visual blood pressure measurements were performed. The general data blood pressure indicators and systemic inflammatory indicators neutrophil/lymphocyte ratio(NLR) and platelet/lymphocyte ratio (PLR) of the two groups were collected and compared. Pearson correlation analysis was used to analyze the relationship between the clinical factors and blood pressure indicators in PV patients, univariate and multivariate logistic regression analysis was used to analyze the related factors of PV incidence, and receiver operating characteristic (ROC) curve was used to analyze the predicted value and cut-off value of each factor in PV incidence. Results After adjustment of interference factors, compared with the healthy control group, the peripheral blood PLR, NLR, cardiac ejection ability (systolic blood pressure,K-D), peripheral arteriole resistance (diastolic blood pressure, mean blood pressure) and degree of vascular sclerosis (K-A) increased significantly in PV patients (P<0.05), and the vascular elasticity of aorta and great artery (pulse pressure difference) and the ability of autonomic nerve to control blood pressure stability (DKT morphology) were decreased significantly (P<0.05). Multivariate logistic regression analysis showed that BMI, PLR, systolic blood pressure, DKT morphology were the independent risk factors for PV (OR=1.270, 1.014, 1.078, 6.084, P<0.05). ROC curve analysis showed that systolic blood pressure (AUC=0.798, P<0.001), mean blood pressure (AUC=0.748, P<0.001), pulse pressure difference (AUC=0.719, P=0.001), diastolic blood pressure (AUC=0.696,P=0.002), NLR (AUC=0.718, P=0.001), PLR (AUC=0.716, P=0.001), K-D (AUC=0.637, P=0.030), and DKT morphology(AUC=0.638, P=0.029) were the early predicted indicators of PV, the cut-off values are 109 mmHg, 86 mmHg, 35 mmHg, 86 mmHg,1.3, 97, 68 and morphology 2, respectively. Conclusion Based on DKT, PV patients have abnormal cardiovascular function, which is related to the occurrence and severity of PV. Abnormal cardiovascular function and systemic inflammatory indexes NLR and PLR have early predictive significance for the occurrence of PV.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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