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Correlation between mitochondrial copy number in IVF embryos and clinical outcome in patients with poor ovarian response
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Na-Na Kong1, Wei-Zhou Wang2, Fu Chen1, Bin Liu1, Hai-Yang Zuo1, Ke-Xin Shen1, 3, Wei Shang2, *
Medical Journal of Chinese People’s Liberation Army | 2022, 47(12) : 1226 - 1231
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Medical Journal of Chinese People’s Liberation Army | 2022, 47(12): 1226-1231
• Clinical Research •
Correlation between mitochondrial copy number in IVF embryos and clinical outcome in patients with poor ovarian response
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Na-Na Kong1, Wei-Zhou Wang2, Fu Chen1, Bin Liu1, Hai-Yang Zuo1, Ke-Xin Shen1, 3, Wei Shang2, *
Affiliations
  • 1Center for Assisted Reproductive Medicine, Department of Obstetrics and Gynecology, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China
  • 2Department of Obstetrics and Gynecology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China
  • 3Department of Obstetrics and Gynecology, Medical College, South China University of Technology, Guangzhou, Guangdong 510006, China
Published: 2022-12-28 doi: 10.11855/j.issn.0577-7402.2022.12.1226
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Objective To explore the role of mitochondrial copy number (MCN) of embryos in the outcome of embryo transfer in patients with poor ovarian response (POR) and the correlation with mother's age, embryonic karyotype and blastocyst grade. Methods A retrospective analysis was performed of 75 patients with normal ovarian reserve (NOR) and 74 patients with POR who underwent in vitro fertilization (IVF) and preimplantation genetic testing for aneuploidies (PGT-A) in the Sixth Medical Center of Chinese PLA General Hospital from September 2018 to October 2020. The blastocysts obtained after IVF were biopsied(NOR group: 205; POR group: 135), and 116 and 44 euploid blastocysts were obtained, respectively. The MCN of embryos in different clinical outcomes of each group were analyzed and compared, and the correlations of embryo MCN with maternal age, embryo karyotype and blastocyst grade were analyzed by multiple linear regression analysis. Results The mean MCN of biopsy blastocysts and euploid blastocysts were lower in POR group than those in NOR group with statistically significant difference (biopsy blastocysts: 267.4±174.0 vs. 319.0±264.8, P<0.05; euploid blastocysts: 216.0±95.7 vs. 305.4±273.2, P<0.01). Regardless POR group or NOR group, the MCN of early aborted embryos was higher than that of live embryos with statistically significant difference(POR group: 303.3±95.4 vs. 158.9±36.3, P<0.01; NOR group: 486.0±356.7 vs. 258.0±137.9, P<0.05). Multiple linear regression analysis showed the MCN of embryos in POR and NOR groups had no correlation with embryo karyotype and blastocyst grade, but was positively correlated with the mother's age (POR group: β=0.185, P=0.035; NOR group: β=0.215, P=0.002). Conclusion Higher MCN may be more likely to cause early miscarriage in POR patients, and the embryonic MCN was correlated with maternal age.

poor ovarian response  /  mitochondrial copy number  /  early miscarriage  /  in vitro fertilization
Na-Na Kong, Wei-Zhou Wang, Fu Chen, Bin Liu, Hai-Yang Zuo, Ke-Xin Shen, Wei Shang. Correlation between mitochondrial copy number in IVF embryos and clinical outcome in patients with poor ovarian response[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (12) : 1226 -1231 . DOI: 10.11855/j.issn.0577-7402.2022.12.1226
Funding
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  • National Key Research and Development Program(2018YFC1003003)
  • Innovation and Cultivation Fund of the Sixth Medical Center of PLA General Hospital(CXPY201807)
Appendix
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Year 2022 volume 47 Issue 12
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113
46
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Article Info
doi: 10.11855/j.issn.0577-7402.2022.12.1226
  • Receive Date：2022-02-07
  • Online Date：2025-12-14
  • Published：2022-12-28
Article Data
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History
  • Received：2022-02-07
  • Accepted：2022-07-15
Funding
National Key Research and Development Program(2018YFC1003003)
Innovation and Cultivation Fund of the Sixth Medical Center of PLA General Hospital(CXPY201807)
Affiliations
    1Center for Assisted Reproductive Medicine, Department of Obstetrics and Gynecology, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China
    2Department of Obstetrics and Gynecology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China
    3Department of Obstetrics and Gynecology, Medical College, South China University of Technology, Guangzhou, Guangdong 510006, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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