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Research progress of action mechanism and treatment of intestinal flora in pathological process of gout
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Xiao-Yun Zhang1, 2, Hua-Nan Li1, *, Shi-Bin Li2, Wei-Wei Wang2, Feng Chen2, Bin Gan1, Yong-Qian Liu1
Medical Journal of Chinese People’s Liberation Army | 2023, 48(1) : 97 - 106
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(1): 97-106
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Research progress of action mechanism and treatment of intestinal flora in pathological process of gout
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Xiao-Yun Zhang1, 2, Hua-Nan Li1, *, Shi-Bin Li2, Wei-Wei Wang2, Feng Chen2, Bin Gan1, Yong-Qian Liu1
Affiliations
  • 1Clinical Medical College of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, China
  • 2Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China
Published: 2023-01-28 doi: 10.11855/j.issn.0577-7402.2023.01.0097
Outline
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Intestinal tract is the largest immune organ of human body where hundreds of millions of microorganisms are colonized which are called intestinal flora. Each intestinal flora checks and balances each other, depends on and complements each other, and forms a mutually beneficial symbiotic relationship with the host. Changes in quantity and type of intestinal flora will cause the imbalance of intestinal microecology, affect the systemic immune function through immune regulation, and then affect the progress of the disease. At present, it has been found that intestinal microecology is closely related to rheumatic immune diseases such as systemic lupus erythematosus, ankylosing spondylitis, gouty arthritis and rheumatoid arthritis. Taking intestinal flora as the starting point to explore the pathogenesis of gout has become a new research hotspot. Based on the current research, the relevant literature was consulted in present paper, and the intestinal microecological composition and function, the structural characteristics of intestinal flora in patients with gout, the mechanism of intestinal flora in the pathogenesis of gout, and the treatment of probiotics, traditional Chinese medicine and fecal microbial transplantation were reviewed, in order to provide new ideas and directions for prevention and treatment of gout in the future.

intestinal flora  /  intestinal microecology  /  gout  /  purine  /  pathogenesis
Xiao-Yun Zhang, Hua-Nan Li, Shi-Bin Li, Wei-Wei Wang, Feng Chen, Bin Gan, Yong-Qian Liu. Research progress of action mechanism and treatment of intestinal flora in pathological process of gout[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (1) : 97 -106 . DOI: 10.11855/j.issn.0577-7402.2023.01.0097
Funding
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  • National Natural Science Foundation of China(81860857)
  • National Natural Science Foundation of China(82060871)
  • Natural Science Foundation of Jiangxi Province(20202BAB206071)
  • Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ190582)
  • Science and Technology Planning Project of Jiangxi Administration of Traditional Chinese Medicine(2020B0333)
  • Construction Project of Deng Yunming National Famous Medical Teacher Studio of Jiangxi Province([2021]-12)
Appendix
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Year 2023 volume 48 Issue 1
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312
147
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.01.0097
  • Receive Date：2021-08-20
  • Online Date：2025-12-03
  • Published：2023-01-28
Article Data
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History
  • Received：2021-08-20
  • Accepted：2022-02-25
Funding
National Natural Science Foundation of China(81860857)
National Natural Science Foundation of China(82060871)
Natural Science Foundation of Jiangxi Province(20202BAB206071)
Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ190582)
Science and Technology Planning Project of Jiangxi Administration of Traditional Chinese Medicine(2020B0333)
Construction Project of Deng Yunming National Famous Medical Teacher Studio of Jiangxi Province([2021]-12)
Affiliations
    1Clinical Medical College of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, China
    2Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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