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Research progress in effects of short-chain fatty acids in intestinal microbial metabolites on depression
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Gao-Qiang Peng1, Ying-Juan Wen1, *, Wu-Ning Tong1, Mo Chen1, Jian-Qin Lv2, Fei Teng3
Medical Journal of Chinese People’s Liberation Army | 2023, 48(2) : 224 - 230
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(2): 224-230
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Research progress in effects of short-chain fatty acids in intestinal microbial metabolites on depression
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Gao-Qiang Peng1, Ying-Juan Wen1, *, Wu-Ning Tong1, Mo Chen1, Jian-Qin Lv2, Fei Teng3
Affiliations
  • 1School of Basic Medicine, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China
  • 2Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
  • 3State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2023-02-28 doi: 10.11855/j.issn.0577-7402.2023.02.0224
Outline
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Intestinal microorganisms are closely related to the pathogenesis of depression, but their specific mechanism of action has not been fully explained. Short-chain fatty acids (SCFA) are metabolites produced by the fermentation of plant polysaccharides, such as dietary fiber and resistant starch mediated by gut microorganisms, which are mainly composed of acetic acid, propionic acid, and butyric acid, and play an important role in the microbiota-intestine-brain axis. Recent studies have found that SCFA can not only regulate intestinal energy metabolism, but also improve depression through blood-brain barrier, immune pathway, endocrine pathway and vagus nerve. SCFA is the focus of scientific research nowadays, and there are few reports on SCFA intervention in depression in China. This article reviews the research progress of SCFA on depression, providing new ideas for clinical research.

intestinal microorganisms  /  short-chain fatty acid  /  depression
Gao-Qiang Peng, Ying-Juan Wen, Wu-Ning Tong, Mo Chen, Jian-Qin Lv, Fei Teng. Research progress in effects of short-chain fatty acids in intestinal microbial metabolites on depression[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (2) : 224 -230 . DOI: 10.11855/j.issn.0577-7402.2023.02.0224
Funding
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  • National Key Research and Development Program(2017YFC1703506)
  • National Natural Science Foundation of China(81202642)
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Year 2023 volume 48 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.02.0224
  • Receive Date：2021-07-29
  • Online Date：2025-12-03
  • Published：2023-02-28
Article Data
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History
  • Received：2021-07-29
  • Accepted：2021-12-03
Funding
National Key Research and Development Program(2017YFC1703506)
National Natural Science Foundation of China(81202642)
Affiliations
    1School of Basic Medicine, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China
    2Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    3State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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