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Effect of Wuzi Yanzong Pill on neurotrophic factors and apoptosis in brain of mice with Parkinson's disease
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Wei Hang1, Hui-Jie Fan1, Yan-Rong Li1, Qi Xiao1, Li-Shan Fan1, Xin-Liang Wang1, Qing Wang1, Bao-Guo Xiao2, Cun-Gen Ma1, 3, *, Zhi Chai1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(2) : 168 - 174
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(2): 168-174
• Basic Research •
Effect of Wuzi Yanzong Pill on neurotrophic factors and apoptosis in brain of mice with Parkinson's disease
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Wei Hang1, Hui-Jie Fan1, Yan-Rong Li1, Qi Xiao1, Li-Shan Fan1, Xin-Liang Wang1, Qing Wang1, Bao-Guo Xiao2, Cun-Gen Ma1, 3, *, Zhi Chai1, *
Affiliations
  • 1Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Neurobiology Research Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
  • 2Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200025, China
  • 3Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037009, China
Published: 2023-02-28 doi: 10.11855/j.issn.0577-7402.2023.02.0168
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Objective To study the effect of Wuzi Yanzong Pill (WYP) on neurotrophic factors and apoptosis in the brain of mice with Parkinson's disease (PD). Methods MPTP-induced PD model in mice was established to evaluate the therapeutic effect of WYP by the behavioral gait, pole test, and brain pathological TH-positive neurons in the substantia nigra (SN). We used immunofluorescence, RT-qPCR, and Western blotting to evaluate the expression of neurotrophic factors (BDNF, GDNF, and CNTF) and apoptosis-associated genes (Bcl-2, Bax, caspase-3, and caspase-9). Results Compared with the PD model group, WYP could reduce the average swinging time of each paw (P<0.05)and pole test time (P<0.001); The number of TH positive cells (P<0.05)and TH protein expression (P<0.05) increased, which inhibited dopaminergic neuron injury. Compared with the PD model group,WYP increased the expression of BDNF, CNTF, GDNF, and Bcl-2 (P<0.05) and decreased the expression of Bax, caspase-3, and caspase-9 (P<0.05). Conclusion WYP shows therapeutic potential in PD, and its mechanism may be related to the anti-apoptotic effect and increased secretion of neurotrophic factors in SN of the brain in the MPTP-induced PD model.

Wuzi Yanzong Pill  /  Parkinson's disease  /  neurotrophic factor  /  apoptosis
Wei Hang, Hui-Jie Fan, Yan-Rong Li, Qi Xiao, Li-Shan Fan, Xin-Liang Wang, Qing Wang, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai. Effect of Wuzi Yanzong Pill on neurotrophic factors and apoptosis in brain of mice with Parkinson's disease[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (2) : 168 -174 . DOI: 10.11855/j.issn.0577-7402.2023.02.0168
Funding
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  • Central Government Guided Local Funding Projects for Science and Technology Development(YDZX20201400001483)
  • Outstanding Youth Talents Program of Shanxi Province
  • Returned Chinese Scholars Technology Activities Preferred Project of Shanxi Province(20200026)
Appendix
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Year 2023 volume 48 Issue 2
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182
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.02.0168
  • Receive Date：2022-02-06
  • Online Date：2025-12-03
  • Published：2023-02-28
Article Data
Affiliations
History
  • Received：2022-02-06
  • Accepted：2022-03-28
Funding
Central Government Guided Local Funding Projects for Science and Technology Development(YDZX20201400001483)
Outstanding Youth Talents Program of Shanxi Province
Returned Chinese Scholars Technology Activities Preferred Project of Shanxi Province(20200026)
Affiliations
    1Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Neurobiology Research Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
    2Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200025, China
    3Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037009, China

Corresponding:

* Chai Zhi, E-mail:
Ma Cun-Gen, E-mail:
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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