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Analysis on the application value of extended non-invasive prenatal genetic testing in prenatal screening
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Yuan-Ling Xiao1, Meng Li2, Gui-Yun Zheng1, Shi-Lei Pan1, Fang Yang1, Shao-Ping Zheng3
Medical Journal of Chinese People’s Liberation Army | 2023, 48(3) : 292 - 297
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(3): 292-297
• Clinical Research •
Analysis on the application value of extended non-invasive prenatal genetic testing in prenatal screening
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Yuan-Ling Xiao1, Meng Li2, Gui-Yun Zheng1, Shi-Lei Pan1, Fang Yang1, Shao-Ping Zheng3
Affiliations
  • 1Obstetrics and Gynecology Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China
  • 2Department of Obstetrics, the Seventh Affiliated Hospital of Southern Medical University, Foshan, Guangdong 528244, China
  • 3The Second Clinical Medical College of Southern Medical University, Guangzhou, Guangdong 510280, China
Published: 2023-03-28 doi: 10.11855/j.issn.0577-7402.2023.03.0292
Outline
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Objective To evaluate the application value of extended non-invasive prenatal genetic testing (NIPT-plus) in prenatal screening. Methods All the NIPT-plus data were collected from Zhujiang Hospital of Southern Medical University and the Seventh Affiliated Hospital of Southern Medical University from January 2018 to June 2021. The abnormal results of NIPT-plus were validated by fetal chromosome examination through amniocentesis. The positive predictive value and negative predictive value of NIPT-plus were analyzed, and the fetal prognosis was followed up. Results A total of 2191 cases were detected, and 38 cases were abnormal (positive rate was 1.7%), among which 6 cases were chromosomal copy number variation. A total of 31 cases were confirmed by amniocentesis, of which 18 cases were consistent with the results of NIPT-plus. The total positive predictive value of NIPT-plus was 58.1%, and the negative predictive value was 100.0%. There were 5 cases of chromosome copy number variation for prenatal diagnosis, of which 3 cases were consistent with the results of NIPT-plus test and the positive predictive value was 60.0%. Conclusion The use of NIPT-plus in prenatal screening has a certain warning value for pregnant women with risk of fetal chromosomal abnormalities.

extended noninvasive prenatal genetic testing  /  prenatal screening  /  ultrasound
Yuan-Ling Xiao, Meng Li, Gui-Yun Zheng, Shi-Lei Pan, Fang Yang, Shao-Ping Zheng. Analysis on the application value of extended non-invasive prenatal genetic testing in prenatal screening[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (3) : 292 -297 . DOI: 10.11855/j.issn.0577-7402.2023.03.0292
Funding
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  • Clinical Research Startup Program of Southern Medical University which funded by High-Level University Construction of Guangdong Provincial Department of Education(LC2016PY035)
Appendix
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Year 2023 volume 48 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.03.0292
  • Receive Date：2021-09-08
  • Online Date：2025-12-03
  • Published：2023-03-28
Article Data
Affiliations
History
  • Received：2021-09-08
  • Accepted：2022-01-18
Funding
Clinical Research Startup Program of Southern Medical University which funded by High-Level University Construction of Guangdong Provincial Department of Education(LC2016PY035)
Affiliations
    1Obstetrics and Gynecology Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China
    2Department of Obstetrics, the Seventh Affiliated Hospital of Southern Medical University, Foshan, Guangdong 528244, China
    3The Second Clinical Medical College of Southern Medical University, Guangzhou, Guangdong 510280, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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