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Correlation between glycocalyx and diseases, and progress in its degradation mechanism
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Jia-Hui Dong1, Hui-Min Li1, Nan-Xi Li1, Guan-Qun Peng2, Yun-Bo Sun1, Gui-Fang Dou1, Shu-Chen Liu1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(3) : 345 - 354
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(3): 345-354
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Correlation between glycocalyx and diseases, and progress in its degradation mechanism
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Jia-Hui Dong1, Hui-Min Li1, Nan-Xi Li1, Guan-Qun Peng2, Yun-Bo Sun1, Gui-Fang Dou1, Shu-Chen Liu1, *
Affiliations
  • 1Institute of Radiation Medicine, Academy of Military Medical Sciences, Military Acadamy of Sciences, Beijing 100850, China
  • 2Life Science College of Hebei University, Baoding, Hebei 071002, China
Published: 2023-03-28 doi: 10.11855/j.issn.0577-7402.2023.03.0345
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With the burgeoning development of glycobiology, a growing body of research shows a significant relationship between the development of various diseases and polysaccharides. Glycocalyx, an important component of the vascular endothelium, has a villi-like structure and plays a highly crucial role in maintaining vascular homeostasis. In-depth multidisciplinary studies have further revealed that the biological functions of glycocalyx are not only limited to vascular homeostasis, but are also closely related to various diseases in vivo. Foundations of glycocalyx composition and biological function, this paper reviews the latest research of glycocalyx biodegradation mechanism from the perspective of biological relevance of glycocalyx main components [heparan sulfate (HS), chondroitin sulfate (CS), hyaluronic acid (HA) and core protein] to cancer, corona virus disease 2019 (COVID-19), trauma surgery and other diseases by visualization and molecular biology experimental methods, and intends to provide new thoughts for clinical development of novel diagnostic methods and therapeutic targets.

glycocalyx  /  biological characteristics  /  visualization  /  diseases  /  mechanism
Jia-Hui Dong, Hui-Min Li, Nan-Xi Li, Guan-Qun Peng, Yun-Bo Sun, Gui-Fang Dou, Shu-Chen Liu. Correlation between glycocalyx and diseases, and progress in its degradation mechanism[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (3) : 345 -354 . DOI: 10.11855/j.issn.0577-7402.2023.03.0345
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.03.0345
  • Receive Date：2022-07-05
  • Online Date：2025-12-03
  • Published：2023-03-28
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History
  • Received：2022-07-05
  • Accepted：2022-09-30
Affiliations
    1Institute of Radiation Medicine, Academy of Military Medical Sciences, Military Acadamy of Sciences, Beijing 100850, China
    2Life Science College of Hebei University, Baoding, Hebei 071002, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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