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Research progress on the relationship of antiviral therapy with HCV-hepatocellular carcinoma
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Ya Deng1, 2, Chun-Yan Wang2, Dong Ji1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(4) : 468 - 475
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(4): 468-475
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Research progress on the relationship of antiviral therapy with HCV-hepatocellular carcinoma
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Ya Deng1, 2, Chun-Yan Wang2, Dong Ji1, 2, *
Affiliations
  • 1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
  • 2Senior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Published: 2023-04-28 doi: 10.11855/j.issn.0577-7402.2023.04.0468
Outline
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Chronic hepatitis C virus (HCV) is a worldwide epidemic and the main cause of liver cirrhosis and hepatocellular carcinoma (HCC). The anti-HCV treatment has gone through two eras of pegylated interferon-α plus ribavirin (PR therapy) and direct-acting antiviral agent (DAA). Generally, achieving a sustained virological response (SVR) can reduce the incidence of HCC through antiviral treatment. In recent years, increasing researchers pay more attention to the issue whether DAA treatment might increase the risk of HCC occurrence or recurrence. This article aims to review the related studies on the risk of HCC after PR therapy and DAA treatment, summarize the risk factors, and explore the mechanism of HCC and its impact on the efficacy of DAA, in order to help clinicians to determine the timing of initiation of antiviral therapy and provide clinical evidence for individualized management.

hepatitis C virus  /  pegylated interferon-α plus ribavirin therapy  /  direct-acting antiviral therapy  /  hepatocellular carcinoma
邓亚, 王春艳, 纪冬. 抗病毒治疗与丙型肝炎病毒相关肝细胞癌的关系研究进展. 解放军医学杂志, 2023 , 48 (4) : 468 -475 . DOI: 10.11855/j.issn.0577-7402.2023.04.0468
Ya Deng, Chun-Yan Wang, Dong Ji. Research progress on the relationship of antiviral therapy with HCV-hepatocellular carcinoma[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (4) : 468 -475 . DOI: 10.11855/j.issn.0577-7402.2023.04.0468
Funding
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  • Medical Big Data and Artificial Intelligence Development Fund of Chinese PLA General Hospital(2019MBD-024)
Appendix
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Year 2023 volume 48 Issue 4
791
454
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.04.0468
  • Receive Date：2021-12-29
  • Online Date：2025-12-03
  • Published：2023-04-28
Article Data
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History
  • Received：2021-12-29
  • Accepted：2022-03-23
Funding
Medical Big Data and Artificial Intelligence Development Fund of Chinese PLA General Hospital(2019MBD-024)
Affiliations
    1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
    2Senior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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