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Study on the relationship between plasma lipoprotein-associated phospholipase A2 and asymptomatic hyperuricemia in the middle-aged and elderly
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Lin-Lin Ma1, Qiong Yang2, Mei-Liang Gong3, Jin-Xing Yu2, Zhou Zhou2, Ya-Hui Lin2, *, Yu-Long Cong3, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(4) : 445 - 450
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(4): 445-450
• Clinical Research •
Study on the relationship between plasma lipoprotein-associated phospholipase A2 and asymptomatic hyperuricemia in the middle-aged and elderly
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Lin-Lin Ma1, Qiong Yang2, Mei-Liang Gong3, Jin-Xing Yu2, Zhou Zhou2, Ya-Hui Lin2, *, Yu-Long Cong3, *
Affiliations
  • 1Medical Laboratory, Associated Hospital of Beihua University, Jilin City, Jilin Province 132011, China
  • 2National Center for Cardiovascular Diseases, Experimental Diagnosis Center, Fuwai Hospital, Chinese Academy of Medical Sciences,Beijing 100037, China
  • 3Medical Laboratory Center, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Published: 2023-04-28 doi: 10.11855/j.issn.0577-7402.2023.04.0445
Outline
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Objective To explore the relativity of asymptomatic hyperuricemia(HUA) to lipoprotein associated phospholipase A2 (Lp-PLA2) in the middle-aged and elderly people. Methods From June 2019 to June 2020, 174 cases of epiphysically healthy middle-aged and elderly people were randomly screened from the Fuwai Hospital of the Chinese Academy of Medical Sciences for physical examination, and were divided into asymptomatic HUA group (n=58) and control group (n=116)according to the diagnostic criteria of HUA.The baseline clinical data of age, sex, body mass index (BMI) and laboratory data of blood routine, uric acid, creatinine, blood urea nitrogen, blood lipid, and Lp-PLA2 were retrospectively analyzed. Regression analysis was used to explore the risk factors of asymptomatic hyperuricemia. Results Among all the subjects, the incidence of HUA was significantly higher in women than in men (41.4% vs. 25.3%, P<0.05). The level of BMI, TG, LDL-C, Lp-PLA2 and the proportion of hypertension in asymptomatic HUA group was significantly higher than that in control group (P<0.05). Compared with the control group by sex, the incidence of HUA is higher in asymptomatic HUA group (P<0.05). The results of multivariate logistic regression analysis indicated that high level of Lp-PLA2 could be independent risk factors of high uric acid level. After divided into three quantile by the concentration of Lp-PLA2, compared with the lowest concentration, the OR value of the highest group increasing the risk of asymptomatic hyperuricemia was 4.61(95%CI 1.807-11.76, P<0.05). Conclusion Lipoprotein associated phospholipase A2 could be an independent risk factor of asymptomatic HUA in middle-aged and elderly adults.

uric acid  /  lipoprotein-associated phospholipase A2  /  asymptomatic hyperuricemia  /  cardiovascular disease
Lin-Lin Ma, Qiong Yang, Mei-Liang Gong, Jin-Xing Yu, Zhou Zhou, Ya-Hui Lin, Yu-Long Cong. Study on the relationship between plasma lipoprotein-associated phospholipase A2 and asymptomatic hyperuricemia in the middle-aged and elderly[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (4) : 445 -450 . DOI: 10.11855/j.issn.0577-7402.2023.04.0445
Funding
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  • National Health of Commission of the People's Republic of China
  • Health Technology Innovation Project of Jilin Province(2020J014)
Appendix
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Year 2023 volume 48 Issue 4
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136
49
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.04.0445
  • Receive Date：2022-02-17
  • Online Date：2025-12-03
  • Published：2023-04-28
Article Data
Affiliations
History
  • Received：2022-02-17
  • Accepted：2022-07-08
Funding
National Health of Commission of the People's Republic of China
Health Technology Innovation Project of Jilin Province(2020J014)
Affiliations
    1Medical Laboratory, Associated Hospital of Beihua University, Jilin City, Jilin Province 132011, China
    2National Center for Cardiovascular Diseases, Experimental Diagnosis Center, Fuwai Hospital, Chinese Academy of Medical Sciences,Beijing 100037, China
    3Medical Laboratory Center, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China

Corresponding:

* Cong Yu-Long, E-mail:
Lin Ya-Hui, E-mail:
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