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Ischemic heart disease (IHD) is one of the diseases with the highest mortality in the world, which endangers human health for a long term. Reperfusion, the preferred treatment strategy, can lead to myocardial deterioration and accelerate injury, known as myocardial ischemia-reperfusion injury (MIRI), which seriously affects the clinical efficacy and prognosis of patients. At present, the prevention and treatment of MIRI is still an unsolved clinical problem. Numerous studies have shown that adaptor protein p66Shc plays an important regulatory role in the occurrence and development of various diseases, including MIRI.The mechanism of adaptor protein p66Shc involved in oxidative stress, inflammatory response and vascular endothelial function in MIRI, and the relevant treatment strategies targeting p66Shc were reviewed in present paper in order to provide a reference for further research on prevention and treatment of MIRI.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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