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Research progress of mesenchymal stem cells and their modifiers in treatment of liver fibrosis
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Jian Ding1, 2, Liang Song1, Bai Ruan2, Lin Wang2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(5) : 609 - 614
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(5): 609-614
• Review •
Research progress of mesenchymal stem cells and their modifiers in treatment of liver fibrosis
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Jian Ding1, 2, Liang Song1, Bai Ruan2, Lin Wang2, *
Affiliations
  • 1Medical Experimental Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 721000, China
  • 2Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an, Shaanxi 710000, China
Published: 2023-05-28 doi: 10.11855/j.issn.0577-7402.2023.05.0609
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Liver fibrosis is a response to chronic liver injury caused by a variety of factors, such as alcohol consumption, viral hepatitis, autoimmune hepatitis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD) and cholestatic liver disease. The combined effect of all these factors on the liver is to produce chronic inflammation leading to an abnormal wound-healing response. Mesenchymal stem cells (MSCs) are pluripotent stem cells that are able to implant into target tissues and secrete a variety of factors that can alter or improve the function of damaged tissues. Stem cells have the advantages of self-renewal, pluripotent differentiation and low immunogenicity. Due to their differentiation potential and paracrine characteristics, MSCs are the key for repair. This review focuses on the mechanism and progress of MSCs and their modifiers in liver fibrosis.

liver fibrosis  /  liver injury  /  mesenchymal stem cell
Jian Ding, Liang Song, Bai Ruan, Lin Wang. Research progress of mesenchymal stem cells and their modifiers in treatment of liver fibrosis[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (5) : 609 -614 . DOI: 10.11855/j.issn.0577-7402.2023.05.0609
Funding
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  • National Natural Science Foundation of China(81800533)
Appendix
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Year 2023 volume 48 Issue 5
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414
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.05.0609
  • Receive Date：2022-02-22
  • Online Date：2025-12-03
  • Published：2023-05-28
Article Data
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History
  • Received：2022-02-22
  • Accepted：2022-06-16
Funding
National Natural Science Foundation of China(81800533)
Affiliations
    1Medical Experimental Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 721000, China
    2Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an, Shaanxi 710000, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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