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Objective To explore the correlation between smoking status and the risk of papillary thyroid carcinoma(PTC) in patients undergoing surgical treatment for thyroid nodules. Methods A retrospective analysis was conducted with the clinical data of 5938 patients (5156 cases with PTC and 782 cases with benign nodules) who underwent surgical resection of thyroid nodules in the First Medical Center of Chinese PLA General Hospital from January 2016 to December 2020, and with complete postoperative pathological results. The general information, serum thyroid hormone (TSH) level, thyroid autoantibody level, and the clinical and pathological characteristics of patients with different smoking status were compared between the two groups. The correlation between smoking status and the risk of PTC in patients of different genders and overall population were analyzed using binary logistic regression analysis. Results There no significant difference in percentage of smokers between PTC group and benign nodule group (P=0.104). The PTC group had a significantly lower proportion of smokers than the benign nodule group for males (P<0.05) rather than for females (P>0.05). For all patients, smokers had a lower proportion of PTC than non-smokers(OR=0.735, 95%CI 0.564-0.959) after adjustment for confounders. In the gender subgroup analysis, a lower risk of PTC was found in smokers than in non-smokers among men (OR=0.635, 95%CI 0.449-0.896), while no association was observed among women(OR=0.910, 95%CI 0.417-1.986) after adjustment for confounders. Conclusion Smoking in males may be associated with a reduced risk of developing PTC in patients undergoing surgical treatment for thyroid nodules.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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