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Phenotypes and individualized treatment of the acute respiratory distress syndrome
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Ni-Mei Xu1, 2, Shuang Zhang1, Zhi-Feng Liu2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(5) : 615 - 620
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(5): 615-620
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Phenotypes and individualized treatment of the acute respiratory distress syndrome
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Ni-Mei Xu1, 2, Shuang Zhang1, Zhi-Feng Liu2, *
Affiliations
  • 1Department of Critical Care Medicine, Jiangmen Central Hospital, Jiangmen, Guangdong 529000, China
  • 2Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Chinese PLA, Guangzhou, Guangdong 510010, China
Published: 2023-05-28 doi: 10.11855/j.issn.0577-7402.2023.05.0615
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Acute respiratory distress syndrome (ARDS) refers to acute diffuse lung injury and subsequent acute respiratory failure caused by various intrapulmonary and extrapulmonary pathogenic factors, with respiratory distress and refractory hypoxemia as clinical features. At present, the "standardized" mechanical ventilation for ARDS patients is a lung protective ventilation strategy with low tidal volume and high positive end-expiratory pressure. However, the results are often unsatisfactory, and most related clinical studies have ended up unsuccessfully. Because of the high heterogeneity of ARDS, accurate classification and individualized treatment are very important. In this paper, we reviewed the phenotypes of ARDS from the perspectives of etiology, onset time, disease severity, inflammation level, imaging characteristics pathology, etc., and preliminarily explained the ARDS phenotype associated with COVID-19, and summarized the individualized treatment strategies for ARDS with different phenotypes, hoping to provide evidence for the individualized and precise treatment of ARDS.

acute respiratory distress syndrome  /  phenotypes  /  individualized treatment  /  coronavirus disease 2019
Ni-Mei Xu, Shuang Zhang, Zhi-Feng Liu. Phenotypes and individualized treatment of the acute respiratory distress syndrome[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (5) : 615 -620 . DOI: 10.11855/j.issn.0577-7402.2023.05.0615
Funding
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  • National Natural Science Foundation of China(82072143)
  • Natural Science Foundation of Guangdong Province(2021A1515010170)
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Year 2023 volume 48 Issue 5
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260
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.05.0615
  • Receive Date：2022-02-28
  • Online Date：2025-12-03
  • Published：2023-05-28
Article Data
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History
  • Received：2022-02-28
  • Accepted：2022-05-04
Funding
National Natural Science Foundation of China(82072143)
Natural Science Foundation of Guangdong Province(2021A1515010170)
Affiliations
    1Department of Critical Care Medicine, Jiangmen Central Hospital, Jiangmen, Guangdong 529000, China
    2Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Chinese PLA, Guangzhou, Guangdong 510010, China

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