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Research progress in efficacy prediction of neoadjuvant chemotherapy for triple negative breast cancer
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Jia-Xu Huang1, 2, Kai-Yuan Huang1, He-Xing Sun1, Yuan-Ke Liang1, Hao-Yu Lin1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(6) : 729 - 734
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(6): 729-734
• Review •
Research progress in efficacy prediction of neoadjuvant chemotherapy for triple negative breast cancer
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Jia-Xu Huang1, 2, Kai-Yuan Huang1, He-Xing Sun1, Yuan-Ke Liang1, Hao-Yu Lin1, *
Affiliations
  • 1Department of Thyroid and Breast Surgery/Clinical Research Center, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China
  • 2Department of Breast Surgery, Jieyang People's Hospital, Jieyang, Guangdong 522000, China
Published: 2023-06-28 doi: 10.11855/j.issn.0577-7402.2023.06.0729
Outline
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Chemotherapy is the main treatment for triple-negative breast cancer (TNBC) due to the lack of effective targeted therapy. At present, neoadjuvant chemotherapy (NAC) is one of the standard treatment strategies. However, the response of patients to NAC is different, and how to identify effective or resistant individuals before treatment is an urgent clinical problem to be solved. The research progress on the prediction of NAC response for TNBC has many aspects, including imageomics, tumor immunology and genomics. Combining different factors to build a prediction model can better improve the prediction efficiency. With the development of gene detection technology, single-cell sequencing technology can exclude the influence of non-tumor cells in tumor microenvironment, accurately determine tumor subtypes, reveal drug resistance mechanisms, and may be applied to NAC in the future to improve the accuracy of prediction. This article reviews the latest research progress in predicting the efficacy of TNBC NAC.

triple negative breast cancer  /  neo-adjuvant chemotherapy  /  curative effect prediction  /  single cell sequencing
Jia-Xu Huang, Kai-Yuan Huang, He-Xing Sun, Yuan-Ke Liang, Hao-Yu Lin. Research progress in efficacy prediction of neoadjuvant chemotherapy for triple negative breast cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (6) : 729 -734 . DOI: 10.11855/j.issn.0577-7402.2023.06.0729
Funding
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  • Youth Program of National Natural Science Foundation of China(82102948)
  • Natural Science Foundation of Guangdong Province(2021A1515012178)
  • Special Fund for Science and Technology of Guangdong Province(210715106900933)
  • Interdisciplinary Project of Li-Ka-Shing Foundation(2020LKSFG05C)
Appendix
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Year 2023 volume 48 Issue 6
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.06.0729
  • Receive Date：2021-10-26
  • Online Date：2025-12-03
  • Published：2023-06-28
Article Data
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History
  • Received：2021-10-26
  • Accepted：2021-12-13
Funding
Youth Program of National Natural Science Foundation of China(82102948)
Natural Science Foundation of Guangdong Province(2021A1515012178)
Special Fund for Science and Technology of Guangdong Province(210715106900933)
Interdisciplinary Project of Li-Ka-Shing Foundation(2020LKSFG05C)
Affiliations
    1Department of Thyroid and Breast Surgery/Clinical Research Center, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China
    2Department of Breast Surgery, Jieyang People's Hospital, Jieyang, Guangdong 522000, China

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