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Advances of miRNA in the diagnosis and treatment of traumatic brain injury
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Ya-Nan Wang1, 2, 3, Dong-Gang Xu2, Chang-Guo Chen3, Wei-Wei Xing2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(6) : 742 - 748
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(6): 742-748
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Advances of miRNA in the diagnosis and treatment of traumatic brain injury
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Ya-Nan Wang1, 2, 3, Dong-Gang Xu2, Chang-Guo Chen3, Wei-Wei Xing2, *
Affiliations
  • 1Academy of Medical Laboratory, Hebei North University, Zhangjiakou, Hebei 075000, China
  • 2Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
  • 3Department of Clinical Laboratory Medicine, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China
Published: 2023-06-28 doi: 10.11855/j.issn.0577-7402.2023.06.0742
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Traumatic brain injury (TBI) is a serious public health problem, and it is estimated that more than 50 million patients worldwide su ff ered from TBI each year. At present, the diagnosis of TBI mainly relies on scoring scales, and it is extremely necessary to screen objective biomarkers of TBI. A large number of studies have focused on the screening of protein markers of TBI, however, protein markers have short half-life and low sensitivity, so it is important to screen new biomarkers of TBI for its rapid diagnostic and treatment. As a lack of effective therapeatic drugs, TBI was mainly treated according to symptoms. microRNAs (miRNAs) are a class of small non-coding RNAs whose altered expression levels are associated with a variety of diseases in central nervous system including TBI and play an important role in the regulation of neuroplasticity and repair of neuronal damage. In addition, its small molecular weight make it crossing the blood-brain barrier conveniently and be easily detected in peripheral fluids. Therefore, miRNAs have the potential to be used as diagnostic markers and therapeutic targets for TBI. This paper aims to review the features of miRNAs and their applications on diagnosis and treatment of TBI, and provide a reference for their potential clinical applications.

traumatic brain injury  /  microRNA  /  diagnostic markers  /  therapeutic targets
Ya-Nan Wang, Dong-Gang Xu, Chang-Guo Chen, Wei-Wei Xing. Advances of miRNA in the diagnosis and treatment of traumatic brain injury[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (6) : 742 -748 . DOI: 10.11855/j.issn.0577-7402.2023.06.0742
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doi: 10.11855/j.issn.0577-7402.2023.06.0742
  • Receive Date：2022-01-07
  • Online Date：2025-12-03
  • Published：2023-06-28
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  • Received：2022-01-07
  • Accepted：2022-05-27
Affiliations
    1Academy of Medical Laboratory, Hebei North University, Zhangjiakou, Hebei 075000, China
    2Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
    3Department of Clinical Laboratory Medicine, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China

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