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Research progress of role and mechanism of A1/A2 reactive astrocyte activation in spinal cord injury
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Tai-Cong Liu, Hai-Hong Zhang*
Medical Journal of Chinese People’s Liberation Army | 2023, 48(6) : 723 - 728
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(6): 723-728
• Review •
Research progress of role and mechanism of A1/A2 reactive astrocyte activation in spinal cord injury
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Tai-Cong Liu, Hai-Hong Zhang*
Affiliations
  • Department of Orthopedics, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China
Published: 2023-06-28 doi: 10.11855/j.issn.0577-7402.2023.06.0723
Outline
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Spinal cord injury (SCI) is a devastating neurological and pathological condition that causes severe motor, sensory, and autonomic nerve dysfunction. Although SCI has been treated with varying degrees of success, these treatments have not yet achieved satisfactory results because the pathological molecular mechanisms of SCI are not fully understood. Recent studies have shown that astrocytes can be activated into A1/A2 phenotypes after SCI. The A1 phenotype of reactive astrocytes plays a neurotoxic role, while the A2 phenotype of reactive astrocytes plays a neuroprotective role. A full understanding of the role and activation mechanism of A1/A2 reactive astrocytes in SCI is expected to provide new ideas for the treatment of SCI. This review focuses on the role of A1/A2 reactive astrocytes in SCI, the signaling pathways that regulate the activation of A1/A2 reactive astrocytes, and SCI therapy for astrocytes.

spinal cord injury  /  A1/A2 astrocytes  /  treatment
Tai-Cong Liu, Hai-Hong Zhang. Research progress of role and mechanism of A1/A2 reactive astrocyte activation in spinal cord injury[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (6) : 723 -728 . DOI: 10.11855/j.issn.0577-7402.2023.06.0723
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  • National Natural Science Foundation of China(31960175)
Appendix
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Year 2023 volume 48 Issue 6
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Article Info
doi: 10.11855/j.issn.0577-7402.2023.06.0723
  • Receive Date：2021-10-19
  • Online Date：2025-12-03
  • Published：2023-06-28
Article Data
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History
  • Received：2021-10-19
  • Accepted：2022-05-04
Funding
National Natural Science Foundation of China(31960175)
Affiliations
    Department of Orthopedics, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China

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