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Research progress on MAGE-A4 in tumor diagnosis and immunotherapy
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Wen-Zhang Wu1, Fan Zhang1, Qi Jia1, Yu-Min Li1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(7) : 834 - 840
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(7): 834-840
• Review •
Research progress on MAGE-A4 in tumor diagnosis and immunotherapy
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Wen-Zhang Wu1, Fan Zhang1, Qi Jia1, Yu-Min Li1, 2, *
Affiliations
  • 1Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China
  • 2Gansu Provincial Key Laboratory of Digestive System Cancer, Lanzhou, Gansu 730030, China
Published: 2023-07-28 doi: 10.11855/j.issn.0577-7402.2379.2022.0412
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Immunotherapy has become one of the hopes to ultimately defeat cancer after radiotherapy, chemotherapy and targeted therapy, and tumor-associated antigen is an important target in immunotherapy. As an important member of the melanoma associated antigen-A (MAGE-A) subfamily, MAGE-A4 is highly expressed in various tumor tissues and low expressed in normal tissues except testis and placenta. It is involved in the regulation of cell functions and has important roles in regulating cell cycle, inducing cell differentiation and growth, and participating in epithelial-mesenchymal transformation, which is closely related to the tumorigenesis, progression, metastasis and prognosis. The latest study shows that the phase Ⅱ clinical study of T cell receptor-transgenic T (TCR-T) immunotherapy based on MAGE-A4 target is being carried out. The results of phase Ⅰ study showed that the overall response rate (ORR) was 23.7% and the disease stability was 47.4%, suggesting that TCR-T immunotherapy based on MAGE-A4 target has good clinical application value. This paper summarizes the structure and biological function of MAGE-A4, the latest research progress of various solid tumors and its clinical application, aiming to provide theoretical basis for clinical transformation and immune-targeted therapy of MAGE-A4.

melanoma associated antigen-A4  /  structure  /  function  /  malignant tumor  /  immunotherapy
Wen-Zhang Wu, Fan Zhang, Qi Jia, Yu-Min Li. Research progress on MAGE-A4 in tumor diagnosis and immunotherapy[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (7) : 834 -840 . DOI: 10.11855/j.issn.0577-7402.2379.2022.0412
Funding
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  • Key Science and Technology Project of Gansu Province(20ZD7FA003)
  • Cuiying Student Scientific Research Cultivation Program of Lanzhou University Second Hospital(CYXZ2021-24)
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Year 2023 volume 48 Issue 7
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Article Info
doi: 10.11855/j.issn.0577-7402.2379.2022.0412
  • Receive Date：2021-10-16
  • Online Date：2025-12-03
  • Published：2023-07-28
Article Data
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History
  • Received：2021-10-16
  • Accepted：2021-12-03
Funding
Key Science and Technology Project of Gansu Province(20ZD7FA003)
Cuiying Student Scientific Research Cultivation Program of Lanzhou University Second Hospital(CYXZ2021-24)
Affiliations
    1Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China
    2Gansu Provincial Key Laboratory of Digestive System Cancer, Lanzhou, Gansu 730030, China

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