Home Journals Articles Updates About
CN
image
收藏切换
Research progress on the relationship between high mobility group box 1 and sepsis-associated encephalopathy
收藏切换
PDF
Jiao-Jiao Yuan, Zong-Ping Fang, Xi-Jing Zhang*
Medical Journal of Chinese People’s Liberation Army | 2023, 48(8) : 972 - 977
Less
收藏切换
Medical Journal of Chinese People’s Liberation Army | 2023, 48(8): 972-977
• Review •
Research progress on the relationship between high mobility group box 1 and sepsis-associated encephalopathy
Full
Jiao-Jiao Yuan, Zong-Ping Fang, Xi-Jing Zhang*
Affiliations
  • Department of Critical Care Medicine, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710000, China
Published: 2023-08-28 doi: 10.11855/j.issn.0577-7402.1125.2022.0908
Outline
收藏切换

Sepsis-associated encephalopathy (SAE) is a complex disease with high mortality, an urgent clinical problem to be solved. The mechanism of SAE has not been fully elucidated and there is no effective treatment. Recent study found that high mobility group box 1 (HMGB1) is a late-stage pro-inflammatory mediator with the effect of activating inflammation, besides, HMGB1 plays important role in tissue repair, as well as in sepsis-induced brain injury. Therefore, In-depth research on the relationship between HMGB1 and SAE is expected to provide a new direction for the diagnosis and treatment of SAE. This review focuses on current status of SAE, HMGB1 and the four aspects of HMGB1, including impairment of blood-brain barrier, dysregulation of immune response, oxidative stress and neuronal apoptosis that involved in brain function impairment and SAE.

sepsis  /  sepsis-associated encephalopathy  /  high mobility group box 1
Jiao-Jiao Yuan, Zong-Ping Fang, Xi-Jing Zhang. Research progress on the relationship between high mobility group box 1 and sepsis-associated encephalopathy[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (8) : 972 -977 . DOI: 10.11855/j.issn.0577-7402.1125.2022.0908
Funding
Less
  • National Natural Science Foundation of China(81871603)
  • National Natural Science Foundation of China(82171322)
Appendix
Less
Year 2023 volume 48 Issue 8
PDF
278
120
Cite this Article
BibTeX
Article Info
doi: 10.11855/j.issn.0577-7402.1125.2022.0908
  • Receive Date：2022-05-17
  • Online Date：2025-11-25
  • Published：2023-08-28
Article Data
Affiliations
History
  • Received：2022-05-17
  • Accepted：2022-07-08
Funding
National Natural Science Foundation of China(81871603)
National Natural Science Foundation of China(82171322)
Affiliations
    Department of Critical Care Medicine, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710000, China

Corresponding:

References
Share
https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.1125.2022.0908
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House