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Research progress on the pathogenesis of Parkinson's disease
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Qi Xiao1, Hui-Jie Fan1, Yan-Rong Li1, Rui-Rui Sun1, Lu Jia1, Lei Xu1, Jie-Zhong Wei2, Bao-Guo Xiao3, Cun-Gen Ma1, Zhi Chai1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(8) : 983 - 992
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(8): 983-992
• Review •
Research progress on the pathogenesis of Parkinson's disease
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Qi Xiao1, Hui-Jie Fan1, Yan-Rong Li1, Rui-Rui Sun1, Lu Jia1, Lei Xu1, Jie-Zhong Wei2, Bao-Guo Xiao3, Cun-Gen Ma1, Zhi Chai1, *
Affiliations
  • 1School of Basic Medical Science/Neurobiology Research Center, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi 030619 , China
  • 2Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037009, China
  • 3Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200025, China
Published: 2023-08-28 doi: 10.11855/j.issn.0577-7402.0303.2023.0224
Outline
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Parkinson's disease (PD) is a common chronic inflammatory disease of the nervous system in the middle-aged and elderly. The main pathological basis of PD is the decrease of dopaminergic neurons in the substantia nigra and the formation of Louie bodies. The clinical manifestations of PD are usually quiescent tremor, bradykinesia, enhanced muscle tone and abnormal posture and gait. The pathogenesis of PD is very complex, which may be related to age, environment, heredity, oxidative stress and mitochondrial dysfunction. In this review, we summarized research progress on the mechanisms and treatment methods of α-synuclein, oxidative stress, mitochondrial dysfunction, LRRK2 gene mutation and other factors leading to the degeneration of dopaminergic neurons in PD, in order to provide a reference for basic and clinical research of PD.

Parkinson's disease  /  α-synuclein  /  mitochondrial dysfunction  /  oxidative stress  /  LRRK2 gene mutation
Qi Xiao, Hui-Jie Fan, Yan-Rong Li, Rui-Rui Sun, Lu Jia, Lei Xu, Jie-Zhong Wei, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai. Research progress on the pathogenesis of Parkinson's disease[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (8) : 983 -992 . DOI: 10.11855/j.issn.0577-7402.0303.2023.0224
Funding
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  • Outstanding Youth Talents Program of Shanxi Province (2019 year)
  • Research Project of Shanxi Scholarship Council of China(2021-142)
  • Key Science and Technology R&D Project of Jinzhong(Y213004)
  • Science and Technology Innovation Ability Cultivation Project of Shanxi University of Chinese Medicine(2021PY-QN-03)
Appendix
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Year 2023 volume 48 Issue 8
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297
133
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Article Info
doi: 10.11855/j.issn.0577-7402.0303.2023.0224
  • Receive Date：2022-02-02
  • Online Date：2025-11-25
  • Published：2023-08-28
Article Data
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History
  • Received：2022-02-02
  • Accepted：2022-11-17
Funding
Outstanding Youth Talents Program of Shanxi Province (2019 year)
Research Project of Shanxi Scholarship Council of China(2021-142)
Key Science and Technology R&D Project of Jinzhong(Y213004)
Science and Technology Innovation Ability Cultivation Project of Shanxi University of Chinese Medicine(2021PY-QN-03)
Affiliations
    1School of Basic Medical Science/Neurobiology Research Center, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi 030619 , China
    2Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037009, China
    3Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200025, China

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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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