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Objective The study aimed to investigate the association between the genetic variant of neurofibromatosis 2 (NF2) gene and susceptibility to meningioma in Chinese population and analyze the correlation between NF2 gene polymorphism and meningioma. Methods 215 patients who had underwent neurosurgical treatment and been histologically diagnosed as meningioma were included as the case group in Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital Medical University between May 2010 to January 2011. The NF2 gene polymorphisms including rs2530673 and rs2530662 were analyzed by Multiplex SNaPshot methods. The correlation between NF2 gene polymorphism and prognosis of meningioma was analyzed. Results The NF2 gene polymorphisms rs2530673 and rs2530662 are not significant associated with the susceptibility to meningioma (P>0.05). According to the WHO grade I pathological subtypes, the result of stratification analysis showed that the patients carrying NF2 gene polymorphism loci rs2530673 CC genotype reduced the risk of transitional meningiomas in the dominant model distribution (OR=0.506, 95%CI 0.266-0.962, P=0.036). Besides, no significant association was found between NF2 gene polymorphism loci rs2530673 and rs2530662 and the recurrence of meningioma (P>0.05). For tumor location, the result of stratification analysis showed that the rs2530673 polymorphism of NF2 gene was associated with postoperative recurrence of meningiomas and patients carrying the rs2530673 CC genotype had shorter progression free survival time and higher recurrence risk in non-skull base meningiomas (all P<0.05). No significant correlation was found between rs2530673/rs2530662 polymorphisms and the prognosis of meningioma (P>0.05). Conclusions The C allele of rs2530673 may be a protective factor for the oneset of transitional meningioma. There may be no significant association between NF2 gene rs2530673/rs2530662 polymorphisms and the susceptibility in meningioma. However, the rs2530673 polymorphism of NF2 gene was associated with postoperative recurrence of meningiomas and patients carrying the rs2530673 CC genotype had higher recurrence risk in non-skull base meningiomas.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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