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Analysis of treatment outcomes and influencing factors of multidrug-resistant pulmonary tuberculosis patients
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Chen-Hui Pan1, Shun-Xian Zhang1, Shao-Yan Zhang1, Lei Qiu1, Wei Zhou1, Xian-Wei Wu1, Ding-Zhong Wu1, Hui-Yong Zhang1, He-Ping Xiao2, Zhen-Hui Lu1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(9) : 1040 - 1047
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(9): 1040-1047
• Clinical Research •
Analysis of treatment outcomes and influencing factors of multidrug-resistant pulmonary tuberculosis patients
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Chen-Hui Pan1, Shun-Xian Zhang1, Shao-Yan Zhang1, Lei Qiu1, Wei Zhou1, Xian-Wei Wu1, Ding-Zhong Wu1, Hui-Yong Zhang1, He-Ping Xiao2, Zhen-Hui Lu1, *
Affiliations
  • 1Department of Respiratory Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032,China
  • 2Department of Tuberculosis, Shanghai Pulmonary Hospital Affiliated to Tongji University,Shanghai 200433, China
Published: 2023-09-28 doi: 10.11855/j.issn.0577-7402.1102.2023.0120
Outline
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Objective To evaluate the risk factors of treatment outcomes in MDR-PTB patients with long-term treatment regimen in China. Methods 332 patients with MDR-PTB were recruited from 22 sentinel hospitals and 1 tertiary general hospital in 23 Provinces in China from January 2013 to December 2017. The treatment outcomes were investigated retrospectively, and the influencing factors of treatment outcomes were collected and analyzed. Results For the 332 patients, 196 cases were successful (59.04%), 76 cases failed (22.89%), 33 cases lost follow-up (9.94%), 12 cases died (3.61%), and 15 cases were transferred out (4.52%). The main factors affecting the outcome of treatment included age ≥50 years (OR=0.342, 95%CI 0.169-0.690), course of MDR-PTB ≥1 year (OR=0.297, 95%CI 0.108-0.815), irregular treatment (OR=0.429, 95%CI 0.197-0.934), cavities before treatment (OR=0.073, 95%CI 0.026-0.207) and positive sputum culture month 3 (OR=0.161, 95%CI 0.072-0.358), and cavity closure month 6 (OR=15.723, 95%CI 5.690-43.444) is predictor of success. Conclusions The result of this study indicated that age, course of MDR-PTB, irregular treatment, sputum culture in month 3, cavity before treatment and cavity closure in month 6 were the influencing factors of MDR-PTB outcome. In the initial stage of treatment of MDR-PTB patients, sputum culture results in month 3 and CT images have important predictive value for the treatment results of MDR-PTB patients.

Tuberculosis, pulmonary  /  Mycobacterium tuberculosis, multidrug-resistant  /  treatment outcome  /  risk factors
Chen-Hui Pan, Shun-Xian Zhang, Shao-Yan Zhang, Lei Qiu, Wei Zhou, Xian-Wei Wu, Ding-Zhong Wu, Hui-Yong Zhang, He-Ping Xiao, Zhen-Hui Lu. Analysis of treatment outcomes and influencing factors of multidrug-resistant pulmonary tuberculosis patients[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (9) : 1040 -1047 . DOI: 10.11855/j.issn.0577-7402.1102.2023.0120
Funding
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  • Fund of the 13th Five-Year Plan National Science and Technology Major Project for Infectious Diseases(2018ZX10725-509)
  • Medical Innovation Research Special Project "Science and Technology Innovation Action Plan" of Shanghai(21Y11922500)
  • Three-Year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals of Shanghai(SHDC2022CRS039)
  • Talent Fund of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(LH001.007)
Appendix
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Year 2023 volume 48 Issue 9
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183
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Article Info
doi: 10.11855/j.issn.0577-7402.1102.2023.0120
  • Receive Date：2022-05-13
  • Online Date：2025-11-25
  • Published：2023-09-28
Article Data
Affiliations
History
  • Received：2022-05-13
  • Accepted：2022-08-28
Funding
Fund of the 13th Five-Year Plan National Science and Technology Major Project for Infectious Diseases(2018ZX10725-509)
Medical Innovation Research Special Project "Science and Technology Innovation Action Plan" of Shanghai(21Y11922500)
Three-Year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals of Shanghai(SHDC2022CRS039)
Talent Fund of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(LH001.007)
Affiliations
    1Department of Respiratory Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032,China
    2Department of Tuberculosis, Shanghai Pulmonary Hospital Affiliated to Tongji University,Shanghai 200433, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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