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Research progress on the regulatory role and mechanism of mesenchymal stem cells in pyroptosis
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Sheng Yang1, Bo Meng1, Qing Peng2, Wen-Jie Zhao1, Man Hu1, Yu Zhang2, Liang Zhang2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(10) : 1221 - 1228
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(10): 1221-1228
• Review •
Research progress on the regulatory role and mechanism of mesenchymal stem cells in pyroptosis
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Sheng Yang1, Bo Meng1, Qing Peng2, Wen-Jie Zhao1, Man Hu1, Yu Zhang2, Liang Zhang2, *
Affiliations
  • 1Graduate School of Dalian Medical University, Dalian, Liaoning 116044, China
  • 2Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, China
Published: 2023-10-28 doi: 10.11855/j.issn.0577-7402.0080.2022.1024
Outline
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Pyroptosis is a caspase-dependent, gasdermin protein mediated inflammatory programmed cell death mode, which is involved in the occurrence and development of a variety of diseases. Mesenchymal stem cells (MSCs) are adult pluripotent stem cells derived from the mesoderm and widely distributed in various tissues of human body and show strong secretory capacity. Exosomes, microvesicles, cytokines and other substances secreted by MSCs can regulate microglia phenotypic transformation, promote mitochondrial autophagy, protect mitochondrial function, regulate endoplasmic reticulum stress and calcium homeostasis, thereby inhibiting the pyroptosis mediated by inflammasome and improving the progression and prognosis of related diseases. In addition, pyroptosis has also been reported in MSCs itself. In present paper, the research progress has been reviewed on the role and mechanism of MSCs in regulating pyroptosis, so as to deepen people's understanding on the relationship between MSCs and cell pyroptosis.

mesenchymal stem cells  /  pyroptosis  /  exosomes  /  research progress
Sheng Yang, Bo Meng, Qing Peng, Wen-Jie Zhao, Man Hu, Yu Zhang, Liang Zhang. Research progress on the regulatory role and mechanism of mesenchymal stem cells in pyroptosis[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (10) : 1221 -1228 . DOI: 10.11855/j.issn.0577-7402.0080.2022.1024
Funding
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  • National Natural Science Foundation of China(82172462)
  • National Natural Science Foundation of China(81972136)
  • Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province(YB2020085)
  • High-level Health Professionals "Six ONE Projects" Top-notch Talent Research Program of Jiangsu Province(LGY2019035)
Appendix
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Year 2023 volume 48 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.0080.2022.1024
  • Receive Date：2022-01-10
  • Online Date：2025-11-25
  • Published：2023-10-28
Article Data
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History
  • Received：2022-01-10
  • Accepted：2022-04-25
Funding
National Natural Science Foundation of China(82172462)
National Natural Science Foundation of China(81972136)
Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province(YB2020085)
High-level Health Professionals "Six ONE Projects" Top-notch Talent Research Program of Jiangsu Province(LGY2019035)
Affiliations
    1Graduate School of Dalian Medical University, Dalian, Liaoning 116044, China
    2Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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