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Objective To evaluate the clinical value to characterize abdominal lymphadenopathy in autoimmune liver diseases (AILD) patients using computed tomography (CT). Methods We recruited 136 AILD patients (set as AILD group) from January 2015 to December 2019 and 65 patients with other liver diseases (set as control group). We assessed the volume and number of the enlarged lymph nodes in different lymph centers using CT. To evaluate the diagnosis value of abdominal lymphadenopathy for AILD, we calculated the area under the receiver operating characteristic curve (AUROC) of abdominal lymphadenopathy. We further employed logistic regression to analyze the risk factors associated with perihepatic lymph node enlargement. Results The abdominal lymph nodes in AILD group had significantly increased average volume and number than those in control group [(0.47±0.61) cm3 vs. (0.25±0.20) cm3;8.10±4.97 vs. 4.26±3.25, P<0.001]. The combination of the number of hepatic lymph nodes and the volume of mesenteric lymph nodes showed well diagnostic value for AILD (AUROC=0.816, P<0.001). Within 77 AILD patients, who underwent liver biopsy, patients with positive hepatic lymphadenopathy showed a significantly higher proportion of interface hepatitis in liver tissues than patients with negative hepatic lymphadenopathy (52.31% vs. 16.67%, χ2=5.169, P<0.05). Multivariate analysis showed that the serum IgG level is a risk factor for perihepatic lymph node enlargement (OR=1.012, 95%CI 1.000-1.024, P<0.05). Conclusions The enlargement of hepatic and mesenteric lymph nodes is of value in the differential diagnosis of AILD. Enlargement of hepatic lymph nodes is correlated with the disease activity in AILD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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