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Research progress on the role of exosomes in Parkinson's disease
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Li-Shan Fan1, Hui-Jie Fan1, Yan-Rong Li1, Qi Xiao1, Lu Jia1, Shao-Chen Qin2, Li-Ran Wang3, Bao-Guo Xiao4, Cun-Gen Ma1, Zhi Chai1, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(10) : 1214 - 1220
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(10): 1214-1220
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Research progress on the role of exosomes in Parkinson's disease
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Li-Shan Fan1, Hui-Jie Fan1, Yan-Rong Li1, Qi Xiao1, Lu Jia1, Shao-Chen Qin2, Li-Ran Wang3, Bao-Guo Xiao4, Cun-Gen Ma1, Zhi Chai1, *
Affiliations
  • 1The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Neurobiology Research Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
  • 2The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030024, China
  • 3The Second Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China
  • 4Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200025, China
Published: 2023-10-28 doi: 10.11855/j.issn.0577-7402.0360.2023.0324
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Parkinson's disease (PD) is a common neurodegenerative disease, and its incidence increases with age. The incorrect folding and abnormal aggregation of α-synuclein are the key neuropathological markers of PD. Recent studies have shown that exosomes may also promote the pathological α-synuclein spreads in brain through their transport and transfer functions, further promoting the development of PD, thus participating in the pathogenesis of PD. Exosomes are nanoscale extracellular vesicles, the advantage of its smaller diameter is expected to play a significant role in treatment of PD. This article reviews the related research progress on the role of exosome and its potential clinical application in PD.

exosomes  /  Parkinson's disease  /  α-synuclein
Li-Shan Fan, Hui-Jie Fan, Yan-Rong Li, Qi Xiao, Lu Jia, Shao-Chen Qin, Li-Ran Wang, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai. Research progress on the role of exosomes in Parkinson's disease[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (10) : 1214 -1220 . DOI: 10.11855/j.issn.0577-7402.0360.2023.0324
Funding
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  • Outstanding Youth Talents Program of Shanxi Province (2019)
  • Research Project Supported by Shanxi Scholarship Council of China(2021-142)
  • Leading Talents Project of Medical Science and Technology of Shanxi Province(2020RC05)
  • Key Science and Technology R and D Project of Jinzhong(Y213004)
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Year 2023 volume 48 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.0360.2023.0324
  • Receive Date：2022-02-18
  • Online Date：2025-11-25
  • Published：2023-10-28
Article Data
Affiliations
History
  • Received：2022-02-18
  • Accepted：2022-04-13
Funding
Outstanding Youth Talents Program of Shanxi Province (2019)
Research Project Supported by Shanxi Scholarship Council of China(2021-142)
Leading Talents Project of Medical Science and Technology of Shanxi Province(2020RC05)
Key Science and Technology R and D Project of Jinzhong(Y213004)
Affiliations
    1The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Neurobiology Research Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
    2The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030024, China
    3The Second Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China
    4Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200025, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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