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Association between triglyceride glucose index and its related derivative index and metabolic associated fatty liver disease in the elderly men
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Juan Kang1, Wen-Hui Liu2, Qing Chang2, Ying-Jie Zhuang2, *
Medical Journal of Chinese People’s Liberation Army | 2023, 48(11) : 1344 - 1352
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(11): 1344-1352
Clinical Research
Association between triglyceride glucose index and its related derivative index and metabolic associated fatty liver disease in the elderly men
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Juan Kang1, Wen-Hui Liu2, Qing Chang2, Ying-Jie Zhuang2, *
Affiliations
  • 1Department of Emergency Medicine, Outpatient Department of the Second Medical Center/National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
  • 2Department of Gastroenterology, the Second Medical Center/National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
Published: 2023-11-28 doi: 10.11855/j.issn.0577-7402.0544.2023.1012
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Objective To explore the association between triglyceride glucose (TyG) index and TyG-body mass index (TyG-BMI) and the prevalence of metabolic associated fatty liver disease (MAFLD) in the elderly men. Methods Totally 2290 elderly men were selected from January to December in 2021 in the Second Medical Center of Chinese PLA General Hospital, and divided into MAFLD group (n=1322) and non-MAFLD group (n=968). Multivariate logistic regression was used to analyze the association between TyG index, TyG-BMI and MAFLD. The receiver operating characteristic (ROC) curve was drawn to explore the predictive value of TyG index and TyG-BMI with MAFLD in the elderly men. Results Two thousand two hundred and ninety elderly men were (74.3±10.1) years old, and an average BMI of (24.63±2.70) kg/m2. BMI, γ‑glutamyl transaminase (γ‑GT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine (Scr), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), the rate of smoking and drinking, and the prevalence of hypertension, diabetes, hyperuricemia, high triglyceride (TG), low high density lipoprotein cholesterol (HDL-C), hyperuricemia, thyroid nodules and cholelithiasis were all significantly higher in non-MAFLD group than those in MAFLD group (P<0.05), while the age of MAFLD group was lower than that of non-MAFLD group (P=0.003). Multivariate logistic regression analysis showed that the risk of MAFLD in patients of TyG quartile groups Q2, Q3, Q4 was 1.667 (95%CI 1.257-2.236, P<0.001), 2.004 (95%CI 1.482-2.710, P<0.001) and 5.420 (95%CI 3.266-8.995, P<0.001) times higher than that of TyG Q1, respectively. The risk of MAFLD in patients of TyG-BMI Q2, Q3, Q4 was 2.215 (95%CI 1.549-3.167, P<0.001), 2.809 (95%CI 1.723-4.580, P<0.001) and 2.513 (95%CI 1.253-5.040, P=0.009) times higher than that of TyG-BMI Q1, respectively. The ROC curve showed that areas under the curve (AUC) of MAFLD predicted by TyG index and TyG-BMI were 0.717 (95%CI 0.696-0.738) and 0.840 (95%CI 0.823-0.856), and the best cut-off values were 8.63 and 205.20, respectively. Moreover, the ROC curve showed that AUC of MAFLD in the elderly men without hyperlipidemia or diabetes predicted by TyG index and TyG-BMI were 0.653 (95%CI 0.622-0.684) and 0.840 (95%CI 0.818-0.862), and the best cut-off values were 8.42 and 202.66, respectively. In addition, AUC, accuracy, specificity, sensitivity, positive predictive value and negative predictive value predicted by TyG-BMI were higher than those by TyG index. Conclusions TyG index and TyG-BMI are significantly associated with MAFLD in the elderly men. Both TyG index and TyG-BMI have certain predictive value for the prevalence of MAFLD in the elderly men, and TyG-BMI may be better.

non-alcoholic fatty liver disease  /  triacylglycerol  /  glucose  /  body mass index  /  receiver operating characteristic curve
Juan Kang, Wen-Hui Liu, Qing Chang, Ying-Jie Zhuang. Association between triglyceride glucose index and its related derivative index and metabolic associated fatty liver disease in the elderly men[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (11) : 1344 -1352 . DOI: 10.11855/j.issn.0577-7402.0544.2023.1012
Year 2023 volume 48 Issue 11
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doi: 10.11855/j.issn.0577-7402.0544.2023.1012
  • Receive Date:2023-04-17
  • Online Date:2025-11-24
  • Published:2023-11-28
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  • Received:2023-04-17
  • Accepted:2023-08-16
Affiliations
    1Department of Emergency Medicine, Outpatient Department of the Second Medical Center/National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
    2Department of Gastroenterology, the Second Medical Center/National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China

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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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