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Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients
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Jing-Chun Song1, *, Gang Wang2, Yun-Hai Fang3, Hai-Ying Wu4, Hai-Yan Yin5, Jin-Hua Zhang6, Ke-Lu7, Ren-Yu Ding8, Zhou Zhou9, Chinese Society of Thrombosis, Hemostasis and Critical, Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association
Medical Journal of Chinese People’s Liberation Army | 2023, 48(12) : 1359 - 1369
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Medical Journal of Chinese People’s Liberation Army | 2023, 48(12): 1359-1369
• Guideline and Consensus •
Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients
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Jing-Chun Song1, *, Gang Wang2, Yun-Hai Fang3, Hai-Ying Wu4, Hai-Yan Yin5, Jin-Hua Zhang6, Ke-Lu7, Ren-Yu Ding8, Zhou Zhou9, Chinese Society of Thrombosis, Hemostasis and Critical, Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association
Affiliations
  • 1Department of Critical Care Medicine, the 908th Hospital of Joint Logistics Support Forces of Chinese PLA, Nanchang, Jiangxi 330002, China
  • 2Department of Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China
  • 3Hemophilia Diagnosis and Treatment Center, Shandong Blood Center, Jinan, Shandong 250013, China
  • 4Emergency Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
  • 5Department of Critical Care Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China
  • 6Pharmacy Department, Fujian Provincial Maternity and Child Health Hospital, Fuzhou, Fujian 350005, China
  • 7Department of Critical Care Medicine, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China
  • 8Department of Critical Care Medicine, the First Affiliated Hospital of Chinese Medical University, Shenyang, Liaoning 110001, China
  • 9Department of Laboratory Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
Published: 2023-12-28 doi: 10.11855/j.issn.0577-7402.1079.2023.1103
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The prothrombin complex concentrate (PCC) is a blood product that mainly contains vitamin K-dependent coagulation factors. PCC has been used clinically for more than 70 years, and its safety has been significantly improved. It has been widely used in the treatment of coagulation disorders or severe bleeding in critically ill patients. If used improperly, it may weaken the hemostatic effect or increase the risk of thrombosis. In order to standardize the rational use of PCC, Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association have organized the formulation of this expert consensus, including three parts: definition, indications, and monitoring and evaluation of efficacy, with a total of 10 suggestions, aiming to help clinicians reasonably use PCC and improve the treatment in critical illness.

prothrombin complex concentrate  /  blood coagulation factors  /  critical illness  /  hemorrhage
Jing-Chun Song, Gang Wang, Yun-Hai Fang, Hai-Ying Wu, Hai-Yan Yin, Jin-Hua Zhang, Ke-Lu, Ren-Yu Ding, Zhou Zhou, Chinese Society of Thrombosis, Hemostasis and Critical, Chinese Medicine Education Association, People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society of Thrombosis and Hemostasis, Chinese Research Hospital Association. Chinese expert consensus on the rational use of prothrombin complex concentrate in critically ill patients[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (12) : 1359 -1369 . DOI: 10.11855/j.issn.0577-7402.1079.2023.1103
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Article Info
doi: 10.11855/j.issn.0577-7402.1079.2023.1103
  • Receive Date：2023-08-14
  • Online Date：2025-11-24
  • Published：2023-12-28
Article Data
Affiliations
History
  • Received：2023-08-14
  • Accepted：2023-08-21
Affiliations
    1Department of Critical Care Medicine, the 908th Hospital of Joint Logistics Support Forces of Chinese PLA, Nanchang, Jiangxi 330002, China
    2Department of Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China
    3Hemophilia Diagnosis and Treatment Center, Shandong Blood Center, Jinan, Shandong 250013, China
    4Emergency Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
    5Department of Critical Care Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China
    6Pharmacy Department, Fujian Provincial Maternity and Child Health Hospital, Fuzhou, Fujian 350005, China
    7Department of Critical Care Medicine, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China
    8Department of Critical Care Medicine, the First Affiliated Hospital of Chinese Medical University, Shenyang, Liaoning 110001, China
    9Department of Laboratory Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China

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