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Heat stroke (HS) is a serious life-threatening disease caused by heat injury and characterized by a core body temperature >40 ℃ with central nervous system dysfunction and multi-organ failure. The main pathophysiological manifestations of HS are the thermal acute phase response and thermoregulatory imbalance. Proteins are particularly sensitive to heat, and the thermal environment can cause massive protein denaturation, resulting in the deposition of unfolded and misfolded proteins in the cytoplasm, causing cellular dysfunction and even death. The unfolded protein response (UPR), mainly divided into the endoplasmic reticulum UPR and the mitochondrial UPR, is an important physiological process that helps proteins to fold correctly or degrade irretrievably denatured proteins. This paper summarizes the regulatory mechanisms of UPR, the relationship between UPR and severe diseases, as well as the relationship between HS and UPR to provide new ideas for the treatment of HS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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