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Total neoadjuvant therapy for locally advanced rectal cancer
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Di Zhou, Jun-Jun Zhou, Bin Hu, Hai-Yan Chen*
Medical Journal of Chinese People’s Liberation Army | 2024, 49(1) : 17 - 22
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(1): 17-22
• Special Issue on Rectal Cancer Surgery and Perioperative Treatment Strategies •
Total neoadjuvant therapy for locally advanced rectal cancer
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Di Zhou, Jun-Jun Zhou, Bin Hu, Hai-Yan Chen*
Affiliations
  • Department of Radiation Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Published: 2024-01-28 doi: 10.11855/j.issn.0577-7402.2369.2023.0619
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Diagnosis and treatment of locally advanced rectal cancer (LARC) must be completed by a collaborative model of a multi-disciplinary team. The neoadjuvant chemoradiotherapy significantly reduced the local recurrence rate of LARC, but did not affect the occurrence of distant metastases and overall survival. Total neoadjuvant therapy (TNT), by strengthening the intensity of chemotherapy and extending the time from radiotherapy to surgery, can improve the tumor response rate as well as disease-free survival rate and metastasis-free survival rate. It offers advantages such as enhancing the compliance with chemotherapy, maximizing tumor regression, improving survival and increasing the chance of organ preservation. TNT is a promising treatment model for LARC patients with high risk of distant metastasis or strong desire for organ preservation. With the application of immunotherapy in the field of TNT, the mode of TNT continues to expand. And the exploration of therapeutic predictive markers will help to provide a personalized treatment for patients.

locally advanced rectal cancer  /  total neoadjuvant therapy  /  neoadjuvant chemoradiotherapy  /  disease-free survival  /  organ preservation
Di Zhou, Jun-Jun Zhou, Bin Hu, Hai-Yan Chen. Total neoadjuvant therapy for locally advanced rectal cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (1) : 17 -22 . DOI: 10.11855/j.issn.0577-7402.2369.2023.0619
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Article Info
doi: 10.11855/j.issn.0577-7402.2369.2023.0619
  • Receive Date：2022-11-09
  • Online Date：2025-11-23
  • Published：2024-01-28
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History
  • Received：2022-11-09
  • Accepted：2023-04-06
Affiliations
    Department of Radiation Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

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