Home Journals Articles Updates About
CN
image
收藏切换
Advances in the study of neoantigen pulsed dendritic cell vaccines in tumor immunotherapy
收藏切换
PDF
Tong-Xin Wang1, 2, Fan Zhang1, 2, Xin Yan1, 2, Ya-Ting Zhang1, 2, Yu-Min Li1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(2) : 220 - 228
Less
收藏切换
Medical Journal of Chinese People’s Liberation Army | 2024, 49(2): 220-228
• Review •
Advances in the study of neoantigen pulsed dendritic cell vaccines in tumor immunotherapy
Full
Tong-Xin Wang1, 2, Fan Zhang1, 2, Xin Yan1, 2, Ya-Ting Zhang1, 2, Yu-Min Li1, 2, *
Affiliations
  • 1Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
  • 2Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China
Published: 2024-02-28 doi: 10.11855/j.issn.0577-7402.1986.2023.0524
Outline
收藏切换

Neoantigen pulsed dendritic cell vaccine (Neo-DCVac) is a new type of tumor immunotherapy. Neoantigen is strong immunologic and tumor-specific mutated peptides expressed in a tumor. Neo-DCVac is a therapeutic modality based on the uptake and processing of neoantigens by dendritic cells and their delivery and activation of T cells to trigger the body's immune response for anti-tumor effects. The development of individualized Neo-DCVac based on high-throughput sequencing is expected to be a new direction for precision immunotherapy of tumors. In this review, we discuss construction of individualized Neo-DCVac, clinical application of combination therapy in solid tumors, suitable population for vaccination and the current limitations of Neo-DCVac, aiming to provide a theoretical reference for research on tumor immunotherapy.

neoantigen  /  dendritic cell vaccine  /  tumor  /  immunotherapy
Tong-Xin Wang, Fan Zhang, Xin Yan, Ya-Ting Zhang, Yu-Min Li. Advances in the study of neoantigen pulsed dendritic cell vaccines in tumor immunotherapy[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (2) : 220 -228 . DOI: 10.11855/j.issn.0577-7402.1986.2023.0524
Funding
Less
  • National Natural Science Foundation of China(31770537)
  • Grand Scientific and Technological Project of Gansu Province(20ZD7FA003)
Appendix
Less
Year 2024 volume 49 Issue 2
PDF
171
70
Cite this Article
BibTeX
Article Info
doi: 10.11855/j.issn.0577-7402.1986.2023.0524
  • Receive Date：2022-09-21
  • Online Date：2025-11-23
  • Published：2024-02-28
Article Data
Affiliations
History
  • Received：2022-09-21
  • Accepted：2022-11-04
Funding
National Natural Science Foundation of China(31770537)
Grand Scientific and Technological Project of Gansu Province(20ZD7FA003)
Affiliations
    1Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
    2Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China

Corresponding:

References
Share
https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.1986.2023.0524
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House