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Characteristics of T cell immune responses in adults inoculated with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months
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Jing Wang1, 2, Ya-Qun Li1, 2, Hai-Yan Wang1, 2, Yao-Ru Song2, Jing Li2, 3, Wen-Xin Wang2, 3, Lin-Yu Wan1, 2, Chun-Bao Zhou2, Xing Fan2, *, Fu-Sheng Wang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(2) : 165 - 170
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(2): 165-170
• Clinical Research •
Characteristics of T cell immune responses in adults inoculated with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months
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Jing Wang1, 2, Ya-Qun Li1, 2, Hai-Yan Wang1, 2, Yao-Ru Song2, Jing Li2, 3, Wen-Xin Wang2, 3, Lin-Yu Wan1, 2, Chun-Bao Zhou2, Xing Fan2, *, Fu-Sheng Wang1, 2, *
Affiliations
  • 1The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China
  • 2Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital/National Clinical Research Center for Infectious Diseases, Beijing 100039, China
  • 3Peking University 302 Clinical Medical School, Beijing 100039, China
Published: 2024-02-28 doi: 10.11855/j.issn.0577-7402.0075.2023.0427
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Objective To evaluate the characteristics of different antigen-specific T cell immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after inoculation with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months. Methods Fifteen healthy adults were enrolled in this study and blood samples collected at 12 months after receiving two doses of SARS-CoV-2 inactivated vaccine. The level and phenotypic characteristics of SARS-CoV-2 antigen-specific T lymphocytes were detected by activation-induced markers (AIM) based on polychromatic flow cytometry. Results After 12 months of inoculation with 2 doses of SARS-CoV-2 inactivated vaccine, more than 90% of adults had detectable Spike and Non-spike antigen-specific CD4+ T cells immune responses (Spike: 14/15, P=0.0001; Non-spike: 15/15, P<0.0001). 80% of adults had detectable Spike and Non-spike antigen-specific CD8+ T cells immune responses (Spike: 12/15, P=0.0463; Non-spike: 12/15, P=0.0806). Antigen-specific CD4+ T cells induced by SARS-CoV-2 inactivated vaccination after 12 months were composed of predominantly central memory (CM) and effector memory 1 (EM1) cells. On the other hand, in terms of helper subsets, antigen-specific CD4+ T cells mainly showed T helper 1/17 (Th1/17) and T helper 2 (Th2) phenotypes. Conclusions SARS-CoV-2 inactivated vaccination generates durable and extensive antigen-specific CD4+ T cell memory responses, which may be the key factor for the low proportion of severe coronavirus disease 2019 (COVID-19) infection in China.

severe acute respiratory syndrome coronavirus 2  /  inactivated vaccine  /  T cell immune response
Jing Wang, Ya-Qun Li, Hai-Yan Wang, Yao-Ru Song, Jing Li, Wen-Xin Wang, Lin-Yu Wan, Chun-Bao Zhou, Xing Fan, Fu-Sheng Wang. Characteristics of T cell immune responses in adults inoculated with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (2) : 165 -170 . DOI: 10.11855/j.issn.0577-7402.0075.2023.0427
Funding
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  • Guangzhou Laboratory Emergency Response Project(EKPG21-30-4)
Appendix
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Year 2024 volume 49 Issue 2
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Article Info
doi: 10.11855/j.issn.0577-7402.0075.2023.0427
  • Receive Date：2023-01-14
  • Online Date：2025-11-23
  • Published：2024-02-28
Article Data
Affiliations
History
  • Received：2023-01-14
  • Accepted：2023-03-08
Funding
Guangzhou Laboratory Emergency Response Project(EKPG21-30-4)
Affiliations
    1The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China
    2Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital/National Clinical Research Center for Infectious Diseases, Beijing 100039, China
    3Peking University 302 Clinical Medical School, Beijing 100039, China

Corresponding:

Wang Fu-Sheng, E-mail:
Fan Xing, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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