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Research progress on the effect of α7 nicotinic acetylcholine receptor on perioperative neurocognitive function
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Shang-Kun Si1, Ying-Xue Xu2, Wei-Liang Zhang2, Jia-Fu Ji2, Dong-Bin Zhang2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(3) : 343 - 348
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(3): 343-348
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Research progress on the effect of α7 nicotinic acetylcholine receptor on perioperative neurocognitive function
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Shang-Kun Si1, Ying-Xue Xu2, Wei-Liang Zhang2, Jia-Fu Ji2, Dong-Bin Zhang2, *
Affiliations
  • 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
  • 2Department of Anesthesiology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
Published: 2024-03-28 doi: 10.11855/j.issn.0577-7402.1157.2022.1006
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α7 nicotinic acetylcholine receptor (α7nAChR) is widely expressed in the central nervous system and immune system, and plays a neuro-immunoregulatory role. On the one hand, α7nAChR is involved in the transmission of neurotransmitters, the conduction of excitatory signals and the maintenance of synaptic plasticity, which is of great significance for maintaining the normal and stable neurocognitive function. On the other hand, as an important part of the cholinergic anti-inflammatory pathway, α7nAChR is involved in the regulation of physiological and pathological processes such as inflammatory response, oxidative stress, apoptosis and autophagy in the central system, and plays an immunomodulatory and neuroprotective role, thus being potential target for improving perioperative neurocognitive function. This article reviews the biological characteristics of α7nAChR and its effect on perioperative neurocognitive function, in order to provide ideas and methods for clinical improvement of perioperative neurocognitive function in surgical patients.

α7 nicotinic acetylcholine receptor  /  perioperative period  /  neurocognitive function  /  cholinergic anti-inflammatory pathway  /  central nerve system diseases
Shang-Kun Si, Ying-Xue Xu, Wei-Liang Zhang, Jia-Fu Ji, Dong-Bin Zhang. Research progress on the effect of α7 nicotinic acetylcholine receptor on perioperative neurocognitive function[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (3) : 343 -348 . DOI: 10.11855/j.issn.0577-7402.1157.2022.1006
Funding
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  • Natural Science Foundation of Shandong Province(ZR2021MH168)
  • Natural Science Foundation of Shandong Province(ZR2020MH391)
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Year 2024 volume 49 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.1157.2022.1006
  • Receive Date：2022-05-20
  • Online Date：2025-11-23
  • Published：2024-03-28
Article Data
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History
  • Received：2022-05-20
  • Accepted：2022-09-18
Funding
Natural Science Foundation of Shandong Province(ZR2021MH168)
Natural Science Foundation of Shandong Province(ZR2020MH391)
Affiliations
    1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
    2Department of Anesthesiology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China

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