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Research progress of the cancer-associated fibroblasts in breast cancer
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Yi-Zhu Chen1, Li Zhu2, Yu-Fan Wei3, Xi-Ru Li2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(4) : 482 - 488
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(4): 482-488
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Research progress of the cancer-associated fibroblasts in breast cancer
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Yi-Zhu Chen1, Li Zhu2, Yu-Fan Wei3, Xi-Ru Li2, *
Affiliations
  • 1Chinese PLA Medical School, Beijing 100853, China
  • 2Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • 3School of Medicine of Nankai University, Tianjin 300071, China
Published: 2024-04-28 doi: 10.11855/j.issn.0577-7402.0532.2022.1114
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Breast cancer is one of the most prevalent malignancies in the world, and many advances have been made in various types of tumor research in recent years. With the deepening understanding of tumors, the microenvironment for tumor cell growth has attracted more and more attention for its impact on the development and progression of cancer. Cancer-associated fibroblasts (CAFs) as the most important components of the tumor microenvironment, can release cytokines, exosomes, and so forth in many ways to regulate immune microenvironment, remodel extracellular matrix and promote formation, migration, invasion, and resistance of tumors, while at the same time CAFs can be regulated by tumor cells. This paper attempts to explain the interaction mode between CAFs and tumors in the immune microenvironment and various ways in which CAFs can promote tumor proliferation, growth, invasion, metastasis, drug resistance and other malignant biological behaviors. Finally, the possibility of using CAFs as an early screening technique and new treatment method for breast tumors is discussed.

breast cancer  /  tumor microenvironment  /  cancer-associated fibroblasts
Yi-Zhu Chen, Li Zhu, Yu-Fan Wei, Xi-Ru Li. Research progress of the cancer-associated fibroblasts in breast cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (4) : 482 -488 . DOI: 10.11855/j.issn.0577-7402.0532.2022.1114
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Article Info
doi: 10.11855/j.issn.0577-7402.0532.2022.1114
  • Receive Date：2022-03-10
  • Online Date：2025-11-23
  • Published：2024-04-28
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  • Received：2022-03-10
  • Accepted：2022-07-15
Affiliations
    1Chinese PLA Medical School, Beijing 100853, China
    2Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
    3School of Medicine of Nankai University, Tianjin 300071, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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