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Objective To compare the outcomes of transplant kidneys and patient survival between simultaneous pancreas-kidney transplantation (SPKT) recipients and deceased donor kidney transplant (DDKT) recipients in patients with type 2 diabetes mellitus (T2DM) complicated with end-stage renal disease (ESRD), and to analyze the risk factors affecting patient survival post-SPKT. Methods Clinical and prognostic data of patients who underwent kidney transplantation from January 27, 2003, to January 1, 2021, were retrieved from the United Network for Organ Sharing (UNOS) database. A total of 50 230 cases were selected based on inclusion criteria, with 48 669 cases in DDKT group and 1561 cases in SPKT group. Kaplan-Meier analysis was employed to compare transplant kidney and patient survival between the two groups, and propensity score matching (PSM) was utilized to balance confounding factors between the groups. Cox regression model was used to analyze independent risk factors affecting patient survival post-SPKT. Results Compared with DDKT group, recipients in SPKT group had a younger median age (P<0.001), a higher proportion of males (P<0.001), lower BMI (P<0.001), shorter dialysis and transplant waiting times (P<0.001), a higher percentage of private medical insurance (P<0.001), a lower proportion of previous transplants (P<0.001), a younger age at diabetes diagnosis (P<0.001), and a lower incidence of peripheral vascular disease (P=0.033). Compared with DDKT group, the donors in SPKT group had a younger median age (P<0.001), a higher proportion of males (P<0.001), lower BMI (P<0.001), and a lower prevalence of hypertension and diabetes history (P<0.001). In terms of transplant-related factors, the SPKT group had a shorter donor kidney cold ischemia time (P<0.001), a higher degree of HLA mismatch (P<0.001), and a lower Kidney Donor Profile Index (KDPI) (P<0.001) when compared with DDKT group. The SPKT group had lower serum creatinine levels at discharge (P<0.001), lower rates of postoperative delayed graft function (DGF) and acute rejection (AR) (P<0.001), but longer hospital stays (P<0.001) when compared with DDKT group. Kaplan-Meier survival analysis curves, both original and after propensity score matching (PSM), consistently showed significantly higher transplant kidney and patient survival rates in SPKT group compared with DDKT group (P<0.001). Cox regression model analysis indicated that recipient age, recipient race, donor age, and donor kidney cold ischemia time were independent risk factors influencing patient survival post-SPKT. Conclusions For ESRD patients with T2DM, SPKT offers improved long-term graft and patient survival rates compared with DDKT. Recipient age, recipient ethnicity, donor age, and cold ischemia time for the donor's kidney are independent risk factors affecting post-SPKT patient survival.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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