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The link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy
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Sheng-Jie Xu1, Jia-Qiu Xi2, Xiao-Wen Yu3, Xiao-Fan Meng1, Zhong-Lin Wang3, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(4) : 475 - 481
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(4): 475-481
• Review •
The link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy
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Sheng-Jie Xu1, Jia-Qiu Xi2, Xiao-Wen Yu3, Xiao-Fan Meng1, Zhong-Lin Wang3, *
Affiliations
  • 1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
  • 2the School Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
  • 3Department of Neurology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
Published: 2024-04-28 doi: 10.11855/j.issn.0577-7402.0010.2023.0721
Outline
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Epilepsy is a chronic disease characterized by recurrent, sudden, and excessive synchronous discharge of neurons in the brain, leading to transient brain dysfunction, and inflammatory responses in specific regions within the central nervous system are common features of epilepsy. In recent years, there has been increasing evidence that endoplasmic reticulum stress is involved in the pathology of epilepsy, which activates the unfolded protein response, then regulate and control nuclear factor kappa-B (NF-κB), efficiently induces glial cell activation through the release of pro-inflammatory signals, in turn affects epileptogenesis and seizures by triggering neuroinflammation. This review focuses on the close link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy pathology, aiming to provide insights for a deeper understanding of epilepsy.

epilepsy  /  endoplasmic reticulum stress  /  glial cell  /  inflammatory response
徐圣洁, 席加秋, 于晓雯, 孟晓凡, 王中琳. 内质网应激与胶质细胞激活介导的神经炎症在癫痫中的作用研究进展. 解放军医学杂志, 2024 , 49 (4) : 475 -481 . DOI: 10.11855/j.issn.0577-7402.0010.2023.0721
Sheng-Jie Xu, Jia-Qiu Xi, Xiao-Wen Yu, Xiao-Fan Meng, Zhong-Lin Wang. The link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (4) : 475 -481 . DOI: 10.11855/j.issn.0577-7402.0010.2023.0721
Funding
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  • Shandong Traditional Chinese Medicine Science and Technology Development Project(2019-0108)
  • Chinese Medicine Science and Technology Project of Shandong Province(2020M004)
  • Qilu Internal Medicine Academic School of Blood Turbidity Inheritance Project Fund of China (Lu WeiHan [2021] No. 45)
Appendix
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Year 2024 volume 49 Issue 4
737
359
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Article Info
doi: 10.11855/j.issn.0577-7402.0010.2023.0721
  • Receive Date：2023-01-03
  • Online Date：2025-11-23
  • Published：2024-04-28
Article Data
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History
  • Received：2023-01-03
  • Accepted：2023-03-02
Funding
Shandong Traditional Chinese Medicine Science and Technology Development Project(2019-0108)
Chinese Medicine Science and Technology Project of Shandong Province(2020M004)
Qilu Internal Medicine Academic School of Blood Turbidity Inheritance Project Fund of China (Lu WeiHan [2021] No. 45)
Affiliations
    1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
    2the School Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
    3Department of Neurology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China

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