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Research progress of histone deacetylase and its inhibitors in osteogenesis and odontogenic differentiation of odontogenic stem cells
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Dong-Yu Li1, 2, Xiao-Miao Zhu2, Ji-Rong Zhao1, *, Wen-Xi He3, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(4) : 468 - 474
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(4): 468-474
• Review •
Research progress of histone deacetylase and its inhibitors in osteogenesis and odontogenic differentiation of odontogenic stem cells
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Dong-Yu Li1, 2, Xiao-Miao Zhu2, Ji-Rong Zhao1, *, Wen-Xi He3, *
Affiliations
  • 1College of Life Sciences, Yan'an University, Yan'an, Shaanxi 716000, China
  • 2State Key Laboratory of Military Stomatology/National Clinical Research Center for Oral Diseases/Key Laboratory of Stomatology of Shaanxi Province/Department of Dentistry and Endodontics, School of Stomatology, Air Force Medical University, Xi'an, Shaanxi 710032, China
  • 3Department of Stomatology, Air Force Medical Center, Air Force Medical University, Beijing 100142, China
Published: 2024-04-28 doi: 10.11855/j.issn.0577-7402.2366.2023.0919
Outline
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Histone deacetylases (HDACs) can deacetylate histones, leading to tighter DNA binding, and thereby playing a role in inhibiting gene transcription. On the contrary, histone deacetylase inhibitors (HDACis) can promote chromatin relaxation, enabling various transcription factors to bind specifically to DNA and activate transcription genes. Dental stem cells (DSCs) are human adult stem cells. These cells have the characteristics of less damage and low immune rejection during sampling, and are especially important seed cells in the process of osteogenesis, odontogenesis and other differentiation. A large number of experimental studies have shown that HDACs and HDACis together play important roles in cell division and differentiation, signal transduction, regulation of cellular inflammation and other life processes. This review summarizes the research progress of HDACs and HDACis in regulating osteogenic and odontogenic differentiation of DSCs, aiming to provide insights into the study of the interaction between HDACs and HDACis, and potentially guide clinical application of DSCs in the treatment of tooth and bone injury.

histone deacetylase  /  histone deacetylase inhibitors  /  odontogenic stem cells  /  differentiation
Dong-Yu Li, Xiao-Miao Zhu, Ji-Rong Zhao, Wen-Xi He. Research progress of histone deacetylase and its inhibitors in osteogenesis and odontogenic differentiation of odontogenic stem cells[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (4) : 468 -474 . DOI: 10.11855/j.issn.0577-7402.2366.2023.0919
Funding
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  • National Natural Science Foundation of China(81970932)
  • Shaanxi Natural Science Basic Research Program-Key Project(2022JZ-42)
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Year 2024 volume 49 Issue 4
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Article Info
doi: 10.11855/j.issn.0577-7402.2366.2023.0919
  • Receive Date：2022-11-23
  • Online Date：2025-11-23
  • Published：2024-04-28
Article Data
Affiliations
History
  • Received：2022-11-23
  • Accepted：2023-03-09
Funding
National Natural Science Foundation of China(81970932)
Shaanxi Natural Science Basic Research Program-Key Project(2022JZ-42)
Affiliations
    1College of Life Sciences, Yan'an University, Yan'an, Shaanxi 716000, China
    2State Key Laboratory of Military Stomatology/National Clinical Research Center for Oral Diseases/Key Laboratory of Stomatology of Shaanxi Province/Department of Dentistry and Endodontics, School of Stomatology, Air Force Medical University, Xi'an, Shaanxi 710032, China
    3Department of Stomatology, Air Force Medical Center, Air Force Medical University, Beijing 100142, China

Corresponding:

He Wen-Xi, E-mail:
Zhao Ji-Rong, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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