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Research advances in signal pathways related to active components of Psoralea corylifolia in osteoporosis
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Rui-Qi Wu1, 2, Xiao-Yun Zhang1, *, Qi-Pei Yang1, 2, Qing-Lin Peng1, 2
Medical Journal of Chinese People’s Liberation Army | 2024, 49(5) : 578 - 585
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(5): 578-585
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Research advances in signal pathways related to active components of Psoralea corylifolia in osteoporosis
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Rui-Qi Wu1, 2, Xiao-Yun Zhang1, *, Qi-Pei Yang1, 2, Qing-Lin Peng1, 2
Affiliations
  • 1Department of Orthopaedics, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530011, China
  • 2Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530001, China
Published: 2024-05-28 doi: 10.11855/j.issn.0577-7402.2279.2023.0620
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Osteoporosis (OP) is a systemic bone disease characterized by low bone mass and damage to the microstructure of bone tissue, leading to increased bone fragility and susceptibility to fracture. Owing to its high prevalence, disability and mortality rates, as well as more sequelae, it brings heavy burden to patients and society. In recent years, as the research on the chemical and pharmacological effects of Psoralea corylifolia has made great progress, scholars have isolated compounds such as coumarins, flavonoids and monoterpene phenols, which have anti-OP, anti-oxidation, and anti-inflammatory properties, Psoralea corylifolia has been widely used in the treatment of OP. This article reviews the regulatory mechanism of active ingredients of Psoralea corylifolia in OP lipid metabolism, bone metabolism and oxidative stress, as well as related therapeutic strategies targeting Wnt/β-catenin, PI3K/Akt, PPAR-γ/Wnt, RANKL/RANK/MAPK and NF-κB signaling pathways, in order to provide further reference for the prevention and treatment of OP.

Psoralea corylifolia  /  osteoporosis  /  oxidative stress  /  bone resorption  /  signal pathway
Rui-Qi Wu, Xiao-Yun Zhang, Qi-Pei Yang, Qing-Lin Peng. Research advances in signal pathways related to active components of Psoralea corylifolia in osteoporosis[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (5) : 578 -585 . DOI: 10.11855/j.issn.0577-7402.2279.2023.0620
Funding
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  • National Natural Science Foundation of China(82360937)
  • Guangxi Natural Science Foundation Youth Fund(2023GXNSFAA026075)
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Year 2024 volume 49 Issue 5
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Article Info
doi: 10.11855/j.issn.0577-7402.2279.2023.0620
  • Receive Date：2022-11-03
  • Online Date：2025-11-21
  • Published：2024-05-28
Article Data
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History
  • Received：2022-11-03
  • Accepted：2023-02-27
Funding
National Natural Science Foundation of China(82360937)
Guangxi Natural Science Foundation Youth Fund(2023GXNSFAA026075)
Affiliations
    1Department of Orthopaedics, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530011, China
    2Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530001, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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