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Progress in study of gut non-immune cells and their role in development of inflammatory bowel disease
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Ze-Rui Wang1, Yan-Mei Jiao2, En-Qiang Linghu1, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(5) : 594 - 601
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(5): 594-601
• Review •
Progress in study of gut non-immune cells and their role in development of inflammatory bowel disease
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Ze-Rui Wang1, Yan-Mei Jiao2, En-Qiang Linghu1, *
Affiliations
  • 1Senior Department of Gastroenterology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • 2Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Published: 2024-05-28 doi: 10.11855/j.issn.0577-7402.1031.2024.0117
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Inflammatory bowel disease (IBD) is a kind of immune disease. Although immune cells and related immunological reactions play a crucial role in the pathogenesis, non-immune cells of IBD, including intestinal epithelial cells, stromal cells, and endothelial cells are also involved in this process. Recent studies have shown that gut non-immune cells play an important role in the maintenance of intestinal epithelial homeostasis, matrix remodeling, immune response and inflammation. The composition, gene expression characteristics and cell functions of gut non-immune cells, as well as their role in the occurrence and progression of IBD, have been paid much attention in the field of gut research. In particular, recently, single-cell RNA sequencing (scRNA-seq) technology has initially clarified the gene expression characteristics and cell functions of different subgroups of intestinal cells, and the correlation between these changes and the occurrence and progression of IBD. Therefore, this review summarizes the progress of intestinal non-immune cells in IBD.

inflammatory bowel disease  /  ulcerative colitis  /  Crohn's disease  /  single-cell RNA sequencing  /  epithelial cell  /  mesenchymal cell
Ze-Rui Wang, Yan-Mei Jiao, En-Qiang Linghu. Progress in study of gut non-immune cells and their role in development of inflammatory bowel disease[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (5) : 594 -601 . DOI: 10.11855/j.issn.0577-7402.1031.2024.0117
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Article Info
doi: 10.11855/j.issn.0577-7402.1031.2024.0117
  • Receive Date：2023-08-03
  • Online Date：2025-11-21
  • Published：2024-05-28
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History
  • Received：2023-08-03
  • Accepted：2023-09-26
Affiliations
    1Senior Department of Gastroenterology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
    2Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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