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Research progress on the role of TGR5 in cardiovascular diseases
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Xi Yang1, 2, Xiong-Shan Sun1, 2, Han Luo3, Tao Hu1, 2, Li Zhang1, 2, Jia Wang2, 4, Qiang Wang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(6) : 711 - 717
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(6): 711-717
• Review •
Research progress on the role of TGR5 in cardiovascular diseases
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Xi Yang1, 2, Xiong-Shan Sun1, 2, Han Luo3, Tao Hu1, 2, Li Zhang1, 2, Jia Wang2, 4, Qiang Wang1, 2, *
Affiliations
  • 1Clinical College of Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
  • 2Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
  • 3Department of Respiratory and Critical Care, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
  • 4College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
Published: 2024-06-28 doi: 10.11855/j.issn.0577-7402.0481.2024.0325
Outline
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Takeda G protein-coupled receptor 5 (TGR5) is a bile acid receptor located on the surface of cell membrane, widely distributed in many tissues and cells in the body, and can be directly activated by most bile acids in vivo. TGR5 plays an important role in various physiological and pathophysiological processes, including cellular Ca2+ transport, oxidative stress, cell proliferation, inflammatory responses, and mitochondrial metabolism, thereby maintaining mitochondrial homeostasis and vascular endothelial function, and inhibiting the progression of cardiovascular diseases such as atherosclerosis, myocardial hypertrophy, and cardiac remodeling after myocardial infarction. Currently, with the gradual clinical application of numerous bile acid and bile acid derivatives drugs, it is necessary to further investigate the role of TGR5 in the cardiovascular system, which is an important basis for clinical application of these new drugs. This review discusses the relationship between TGR5 and cardiovascular system from five perspectives: TGR5's involvement in regulating macrophages, endothelial function, vascular smooth muscle cells, cardiomyocytes, and mitochondrial metabolism. It summarizes the recent research progress, aiming to provide the theoretical basis for TGR5 as a novel therapeutic target for cardiovascular diseases.

Takeda G protein coupled receptor 5  /  cardiovascular diseases  /  atherosclerosis  /  bile acid
Xi Yang, Xiong-Shan Sun, Han Luo, Tao Hu, Li Zhang, Jia Wang, Qiang Wang. Research progress on the role of TGR5 in cardiovascular diseases[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (6) : 711 -717 . DOI: 10.11855/j.issn.0577-7402.0481.2024.0325
Funding
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  • National Natural Science Foundation of China(82100419)
  • Sichuan Natural Science Foundation(2022NSFSC0820)
  • Project of General Hospital of Western Theater Comm(2021-XZYG-B28)
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Year 2024 volume 49 Issue 6
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Article Info
doi: 10.11855/j.issn.0577-7402.0481.2024.0325
  • Receive Date：2023-04-12
  • Online Date：2025-11-21
  • Published：2024-06-28
Article Data
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History
  • Received：2023-04-12
  • Accepted：2023-08-24
Funding
National Natural Science Foundation of China(82100419)
Sichuan Natural Science Foundation(2022NSFSC0820)
Project of General Hospital of Western Theater Comm(2021-XZYG-B28)
Affiliations
    1Clinical College of Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
    2Department of Cardiology, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
    3Department of Respiratory and Critical Care, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
    4College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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